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Science 5 October 1984:
Vol. 226. no. 4670, pp. 67 - 70
DOI: 10.1126/science.6474190
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Articles

Science, Vol 226, Issue 4670, 67-70
Copyright © 1984 by American Association for the Advancement of Science

articles

A gradient of sequence divergence in the human adult alpha-globin duplication units

JF Hess, CW Schmid, and CK Shen

The nucleotide sequences of the two 5'-homology blocks of human alpha-globin gene duplication units were determined. The sequence difference between the two blocks is essentially zero in the 5' portions, and increases gradually toward the 3' ends until it reaches a value of 18 percent. This gradient of sequence divergence is similar to the distribution of the frequencies of gene conversion along several loci in Ascobolus and yeast. Hot spots for initiation of gene correction processes appear to exist near the 5' ends of the human alpha-globin duplication units. The data provide the physical evidence for polar gene correction process in a mammalian genome.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Nonuniform Concerted Evolution and Chloroplast Capture: Heterogeneity of Observed Introgression Patterns in Three Molecular Data Partition Phylogenies of Asian Mitella (Saxifragaceae).
Y. Okuyama, N. Fujii, M. Wakabayashi, A. Kawakita, M. Ito, M. Watanabe, N. Murakami, and M. Kato (2005)
Mol. Biol. Evol. 22, 285-296
   Abstract »    Full Text »    PDF »
Molecular origin of the mosaic sequence arrangements of higher primate alpha -globin duplication units.
A. D. Bailey, C. C. Shen, and C.-K. J. Shen (1997)
PNAS 94, 5177-5182
   Abstract »    Full Text »    PDF »
Repetitive Human DNA Sequences: I. Evolution of the Primate {alpha}-Globin Gene Cluster and Interspersed Alu Repeats.
I. Sawada and C.W. Schmid (1986)
Cold Spring Harb Symp Quant Biol 51, 471-477
   Abstract »    PDF »
Repetitive Human DNA Sequences: II. Properties of a Transposon-like Human Element.
N. Deka, K.E. Paulson, C. Willard, and C.W. Schmid (1986)
Cold Spring Harb Symp Quant Biol 51, 473-477
   Abstract »    PDF »
The Primate {alpha}-Globin Gene Family: A Paradigm of the Fluid Genome.
J. Marks, J.-P. Shaw, C. Perez-Stable, W.-S. Hu, T.M. Ayres, C. Shen, and C.-K.J. Shen (1986)
Cold Spring Harb Symp Quant Biol 51, 499-508
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)