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Science 5 October 1984:
Vol. 226. no. 4670, pp. 65 - 67
DOI: 10.1126/science.6382613
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Articles

Science, Vol 226, Issue 4670, 65-67
Copyright © 1984 by American Association for the Advancement of Science

articles

Reversal of knob formation on Plasmodium falciparum-infected erythrocytes

CA Gritzmacher and RT Reese

The human malarial parasite Plasmodium falciparum can produce surface protrusions (knobs) on infected erythrocytes; however, long-term culturing of the parasite results in the appearance of knobless cells. In this study it was found that a knob-producing clone lost the ability to produce knobs in vitro. Furthermore, a clone not producing knobs derived from the knob-producing clone regained the capacity to produce knobby cells in vitro. Certain parasite proteins were associated with the knobby phenotype but not with the knobless type. These results indicate that the parasites change in vitro in a spontaneous and reversible manner independent of immunological selection.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Plasmodium knowlesi Provides a Rapid In Vitro and In Vivo Transfection System That Enables Double-Crossover Gene Knockout Studies.
C. H. M. Kocken, H. Ozwara, A. van der Wel, A. L. Beetsma, J. M. Mwenda, and A. W. Thomas (2002)
Infect. Immun. 70, 655-660
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Science. ISSN 0036-8075 (print), 1095-9203 (online)