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Science 5 October 1984:
Vol. 226. no. 4670, pp. 61 - 65
DOI: 10.1126/science.6089351
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Articles

Science, Vol 226, Issue 4670, 61-65
Copyright © 1984 by American Association for the Advancement of Science

articles

Identification of the putative transforming protein of the human T-cell leukemia viruses HTLV-I and HTLV-II

DJ Slamon, K Shimotohno, MJ Cline, DW Golde, and IS Chen

The human T-cell leukemia viruses HTLV-I and HTLV-II are unique among the transforming retroviruses of vertebrates in their ability to transform human T cells in vitro and in their close association with human malignancies (T-cell lymphomas and leukemia). Their genomes are relatively simple, containing the genes gag, pol, env, and a 3' region termed "X." This 3' region may be responsible for the transforming potential of the viruses. The existence of proteins encoded by the 3' region has been postulated on the basis of multiple open reading frames. In the present study this region is shown to contain a gene encoding a protein of 40 kilodaltons in HTLV-I and 37 kilodaltons in HTLV-II. It is proposed that these proteins be called, respectively, p40xI and p37xII.


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HTLV-II transactivation is regulated by the overlapping tax/rex nonstructural genes.
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Seroprevalence and epidemiological correlates of HTLV-I infection in U.S. blood donors.
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H Kitado, I. Chen, N. Shah, A. Cann, K Shimotohno, and H Fan (1987)
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HTLV x gene mutants exhibit novel transcriptional regulatory phenotypes.
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Identification and characterization of the protein encoded by the human N-myc oncogene.
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A new HTLV-III/LAV encoded antigen detected by antibodies from AIDS patients.
J. Allan, J. Coligan, T. Lee, M. McLane, P. Kanki, J. Groopman, and M Essex (1985)
Science 230, 810-813
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Functional relation between HTLV-II x and adenovirus E1A proteins in transcriptional activation.
I. Chen, A. Cann, N. Shah, and R. Gaynor (1985)
Science 230, 570-573
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The pX protein of HTLV-I is a transcriptional activator of its long terminal repeats.
B. Felber, H Paskalis, C Kleinman-Ewing, F Wong-Staal, and G. Pavlakis (1985)
Science 229, 675-679
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cis- and trans-acting transcriptional regulation of visna virus.
J. Hess, J. Clements, and O Narayan (1985)
Science 229, 482-485
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The x gene is essential for HTLV replication.
I. Chen, D. Slamon, J. Rosenblatt, N. Shah, S. Quan, and W Wachsman (1985)
Science 229, 54-58
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Location of the trans-activating region on the genome of human T-cell lymphotropic virus type III.
J Sodroski, R Patarca, C Rosen, F Wong-Staal, and W Haseltine (1985)
Science 229, 74-77
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Expression of the pX gene of HTLV-I: general splicing mechanism in the HTLV family.
M Seiki, A Hikikoshi, T Taniguchi, and M Yoshida (1985)
Science 228, 1532-1534
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HTLV x-gene product: requirement for the env methionine initiation codon.
W Wachsman, D. Golde, P. Temple, E. Orr, S. Clark, and I. Chen (1985)
Science 228, 1534-1537
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Studies of the putative transforming protein of the type I human T-cell leukemia virus.
D. Slamon, M. Press, L. Souza, D. Murdock, M. Cline, D. Golde, J. Gasson, and I. Chen (1985)
Science 228, 1427-1430
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A transcriptional activator protein encoded by the x-lor region of the human T-cell leukemia virus.
J Sodroski, C Rosen, W. Goh, and W Haseltine (1985)
Science 228, 1430-1434
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Expression in Escherichia coli of open reading frame gene segments of HTLV-III.
N. Chang, P. Chanda, A. Barone, S McKinney, D. Rhodes, S. Tam, C. Shearman, J Huang, T. Chang, R. Gallo, et al. (1985)
Science 228, 93-96
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Subcellular localization of the product of the long open reading frame of human T-cell leukemia virus type I.
W. Goh, J Sodroski, C Rosen, M Essex, and W. Haseltine (1985)
Science 227, 1227-1228
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Nucleotide sequence and expression of an AIDS-associated retrovirus (ARV-2).
R Sanchez-Pescador, M. Power, P. Barr, K. Steimer, M. Stempien, S. Brown-Shimer, W. Gee, A Renard, A Randolph, J. Levy, et al. (1985)
Science 227, 484-492
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Trans-acting transcriptional regulation of human T-cell leukemia virus type III long terminal repeat.
J Sodroski, C Rosen, F Wong-Staal, S. Salahuddin, M Popovic, S Arya, R. Gallo, and W. Haseltine (1985)
Science 227, 171-173
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Sequence homology and morphologic similarity of HTLV-III and visna virus, a pathogenic lentivirus.
M. Gonda, F Wong-Staal, R. Gallo, J. Clements, O Narayan, and R. Gilden (1985)
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Expression of the 3' terminal region of human T-cell leukemia viruses.
W Wachsman, K Shimotohno, S. Clark, D. Golde, and I. Chen (1984)
Science 226, 177-179
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