Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 28 September 1984:
Vol. 225. no. 4669, pp. 1484 - 1486
DOI: 10.1126/science.6206569
Prev | Table of Contents | Next

Articles

Science, Vol 225, Issue 4669, 1484-1486
Copyright © 1984 by American Association for the Advancement of Science

articles

Functional properties of antigen-specific T cells infected by human T-cell leukemia-lymphoma virus (HTLV-I)

H Mitsuya, HG Guo, J Cossman, M Megson, MS Reitz Jr, and S Broder

Tetanus-toxoid specific helper-inducer T-cell clones, which had been infected and transformed by human T-cell leukemia-lymphoma virus (HTLV-I), were obtained from an antigen-specific human T cell line by using a limiting dilution technique in the presence of the virus. These HTLV-I-infected T-cell clones proliferated specifically in response to soluble tetanus toxoid but, unlike normal T cells, they could do so in the absence of accessory cells. The HTLV-I-infected T-cell clones did not present the antigen to autologous antigen-specific T cells that were not infected with HTLV-I. The capacity of helper-inducer T cells to retain antigen-specific reactivity after infection by HTLV-I, while losing the normal T-cell requirement for accessory cells, has clinical and theoretical implications.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Missense mutation of the interleukin-12 receptor {beta}1 chain-encoding gene is associated with impaired immunity against Mycobacterium avium complex infection.
T. Sakai, M. Matsuoka, M. Aoki, K. Nosaka, and H. Mitsuya (2001)
Blood 97, 2688-2694
   Abstract »    Full Text »    PDF »
Mechanisms of T-Cell Activation by Human T-Cell Lymphotropic Virus Type I.
P. Hollsberg (1999)
Microbiol. Mol. Biol. Rev. 63, 308-333
   Abstract »    Full Text »    PDF »
Expression of a zinc finger gene in HTLV-I- and HTLV-II-transformed cells.
J. Wright, K. Gunter, H Mitsuya, S. Irving, K Kelly, and U Siebenlist (1990)
Science 248, 588-591
   Abstract »    PDF »
Suramin protection of T cells in vitro against infectivity and cytopathic effect of HTLV-III.
H Mitsuya, M Popovic, R Yarchoan, S Matsushita, R. Gallo, and S Broder (1984)
Science 226, 172-174
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)