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Science 28 September 1984:
Vol. 225. no. 4669, pp. 1484 - 1486
DOI: 10.1126/science.6206569
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Articles

Science, Vol 225, Issue 4669, 1484-1486
Copyright © 1984 by American Association for the Advancement of Science

articles

Functional properties of antigen-specific T cells infected by human T-cell leukemia-lymphoma virus (HTLV-I)

H Mitsuya, HG Guo, J Cossman, M Megson, MS Reitz Jr, and S Broder

Tetanus-toxoid specific helper-inducer T-cell clones, which had been infected and transformed by human T-cell leukemia-lymphoma virus (HTLV-I), were obtained from an antigen-specific human T cell line by using a limiting dilution technique in the presence of the virus. These HTLV-I-infected T-cell clones proliferated specifically in response to soluble tetanus toxoid but, unlike normal T cells, they could do so in the absence of accessory cells. The HTLV-I-infected T-cell clones did not present the antigen to autologous antigen-specific T cells that were not infected with HTLV-I. The capacity of helper-inducer T cells to retain antigen-specific reactivity after infection by HTLV-I, while losing the normal T-cell requirement for accessory cells, has clinical and theoretical implications.


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