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Science 21 September 1984:
Vol. 225. no. 4668, pp. 1346 - 1350
DOI: 10.1126/science.6089347
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Articles

Science, Vol 225, Issue 4668, 1346-1350
Copyright © 1984 by American Association for the Advancement of Science

articles

Biophysical studies of ion channels

CF Stevens

Ionic channels, the integral membrane proteins responsible for the brain's electrical activity, have long been studied with standard electrophysiological and biochemical methods. Recently, however, newly developed electrical and molecular biological methods have been brought to bear on long-standing questions in neurobiology. Goals of current channel research include elucidating the primary amino acid sequence and three-dimensional structure of channel species; the mechanisms of synthesis, sorting, membrane insertion, and degradation; and aspects of function such as gating, ion permeation and selectivity, and regulation. The latest research combines the new biochemical and electrophysiological techniques to reveal relations between molecular structure and function.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Human Ether-a-go-go-related Gene K+ Channel Gating Probed with Extracellular Ca2+: Evidence for Two Distinct Voltage Sensors.
J.P. Johnson Jr., F. M. Mullins, and P. B. Bennett (1999)
J. Gen. Physiol. 113, 565-580
   Abstract »    Full Text »    PDF »
Neurosciences: an integrative discipline.
S. Snyder (1984)
Science 225, 1255-1257
   PDF »


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