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Science 21 September 1984:
Vol. 225. no. 4668, pp. 1335 - 1345
DOI: 10.1126/science.6382611
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Articles

Science, Vol 225, Issue 4668, 1335-1345
Copyright © 1984 by American Association for the Advancement of Science

articles

Acetylcholine receptor: an allosteric protein

JP Changeux, A Devillers-Thiery, and P Chemouilli

The nicotine receptor for the neurotransmitter acetylcholine is an allosteric protein composed of four different subunits assembled in a transmembrane pentamer alpha 2 beta gamma delta. The protein carries two acetylcholine sites at the level of the alpha subunits and contains the ion channel. The complete sequence of the four subunits is known. The membrane-bound protein undergoes conformational transitions that regulate the opening of the ion channel and are affected by various categories of pharmacologically active ligands.


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