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Science 21 September 1984:
Vol. 225. no. 4668, pp. 1320 - 1326
DOI: 10.1126/science.6089346
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Articles

Science, Vol 225, Issue 4668, 1320-1326
Copyright © 1984 by American Association for the Advancement of Science

articles

DNA markers for nervous system diseases

JF Gusella, RE Tanzi, MA Anderson, W Hobbs, K Gibbons, R Raschtchian, TC Gilliam, MR Wallace, NS Wexler, and PM Conneally

Recombinant DNA technology has provided a vast new source of DNA markers displaying heritable sequence variation in humans. These markers can be used in family studies to identify the chromosomal location of defective genes causing nervous system disorders. The discovery of a DNA marker linked to Huntington's disease has opened new avenues of research into this disorder and may ultimately permit cloning and characterization of the defective gene.


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Neurosciences: an integrative discipline.
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