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Science 21 September 1984:
Vol. 225. no. 4668, pp. 1315 - 1320
DOI: 10.1126/science.6089345
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Articles
Science, Vol 225, Issue 4668, 1315-1320
Copyright © 1984 by American Association for the Advancement of Science
Alternative RNA processing: determining neuronal phenotype
MG Rosenfeld,
SG Amara,
and
RM Evans
On the basis of an analysis of the human and rat calcitonin genes and of a related gene, alternative RNA processing represents a developmental strategy of the brain to dictate tissue-specific patterns of polypeptide synthesis. This regulation allows the calcitonin gene to generate two messenger RNA's, one encoding the precursor of a novel neuropeptide, referred to as CGRP, which predominates in the brain, and the second encoding the precursor to the hormone calcitonin which predominates in thyroid C cells. The distribution of CGRP in the central and peripheral nervous system and in endocrine and other organ systems suggests potential functions in nociception, ingestive behavior, cardiovascular homeostasis, and mineral metabolism.
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