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Science 21 September 1984:
Vol. 225. no. 4668, pp. 1308 - 1315
DOI: 10.1126/science.6474179
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Articles

Science, Vol 225, Issue 4668, 1308-1315
Copyright © 1984 by American Association for the Advancement of Science

articles

Control of neuronal gene expression

JG Sutcliffe, RJ Milner, JM Gottesfeld, and W Reynolds

Some 30,000 genes are expressed exclusively in the rat brain, many of which contain a genetic element called an identifier sequence located in at least one of their introns. The identifier sequences are transcribed by RNA polymerase III exclusively in neurons to produce two RNA species, BC1 and BC2, of 160 and 100 to 110 nucleotides. This transcriptional event may define regions of chromatin that contain neuronal-specific genes and may poise these genes for transcription by polymerase II by rendering the gene promoters accessible to soluble trans-acting molecules.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Neuronal Untranslated BC1 RNA: Targeted Gene Elimination in Mice.
B. V. Skryabin, V. Sukonina, U. Jordan, L. Lewejohann, N. Sachser, I. Muslimov, H. Tiedge, and J. Brosius (2003)
Mol. Cell. Biol. 23, 6435-6441
   Abstract »    Full Text »    PDF »
The Novel Kinase Peptidylglycine alpha -Amidating Monooxygenase Cytosolic Interactor Protein 2 Interacts with the Cytosolic Routing Determinants of the Peptide Processing Enzyme Peptidylglycine alpha -Amidating Monooxygenase.
B. D. Caldwell, D. N. Darlington, P. Penzes, R. C. Johnson, B. A. Eipper, and R. E. Mains (1999)
J. Biol. Chem. 274, 34646-34656
   Abstract »    Full Text »    PDF »
An Alu Element in the Myeloperoxidase Promoter Contains a Composite SP1-Thyroid Hormone-Retinoic Acid Response Element.
F. J. Piedrafita, R. B. Molander, G. Vansant, E. A. Orlova, M. Pfahl, and W. F. Reynolds (1996)
J. Biol. Chem. 271, 14412-14420
   Abstract »    Full Text »    PDF »
Response: Brain "Identifier Sequence".
G. P. OWENS, N. CHAUDHARI, and W. E. HAHN (1986)
Science 234, 1006
   PDF »
Brain "identifier sequence" is not restricted to brain: similar abundance in nuclear RNA of other organs.
G. Owens, N Chaudhari, and W. Hahn (1985)
Science 229, 1263-1265
   Abstract »    PDF »
Neurosciences: an integrative discipline.
S. Snyder (1984)
Science 225, 1255-1257
   PDF »
Biophysical studies of ion channels.
C. Stevens (1984)
Science 225, 1346-1350
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)