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Science 21 September 1984:
Vol. 225. no. 4668, pp. 1287 - 1294
DOI: 10.1126/science.6382610
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Articles

Science, Vol 225, Issue 4668, 1287-1294
Copyright © 1984 by American Association for the Advancement of Science

articles

Cell biology of synaptic plasticity

CW Cotman and M Nieto-Sampedro

The nervous system of mammals retains throughout the animals' life-span the ability to modify the number, nature, and level of activity of its synapses. Synaptic plasticity is most evident after injury to the nervous system, and the cellular and molecular mechanisms that make it possible are beginning to be understood. Transplantation of brain tissue provides a powerful approach for studying mechanisms of synaptic plasticity. In turn, understanding the response of the central nervous system to injury can be used to optimize transplant survival and integration with the host brain.


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