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Science 21 September 1984:
Vol. 225. no. 4668, pp. 1280 - 1287
DOI: 10.1126/science.6474177
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Articles

Science, Vol 225, Issue 4668, 1280-1287
Copyright © 1984 by American Association for the Advancement of Science

articles

Mitogenic growth factors and nerve dependence of limb regeneration

JP Brockes

Regeneration of the amphibian limb after amputation depends on division of blastemal cells, the progenitor cells of the regenerate. This division is controlled, at least in the early stages of regeneration, by the nerve supply to the blastema. A monoclonal antibody to newt blastema cells has provided evidence that Schwann cells and muscle fibers contribute to the blastema, and identifies blastemal cells whose division is persistently dependent on the nerve. Glial growth factor, a molecule identified by its action on rat Schwann cells, is present in the newt blastema and is lost on denervation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Molecular Basis for the Nerve Dependence of Limb Regeneration in an Adult Vertebrate.
A. Kumar, J. W. Godwin, P. B. Gates, A. A. Garza-Garcia, and J. P. Brockes (2007)
Science 318, 772-777
   Abstract »    Full Text »    PDF »
Appendage Regeneration in Adult Vertebrates and Implications for Regenerative Medicine.
J. P. Brockes and A. Kumar (2005)
Science 310, 1919-1923
   Abstract »    Full Text »    PDF »
Limb Regeneration in the Fiddler Crab, Uca pugilator: Hormonal and Growth Factor Control.
P. M. Hopkins (2001)
Integr. Comp. Biol. 41, 389-398
   Abstract »    Full Text »    PDF »
Control of larval development by chemosensory neurons in Caenorhabditis elegans.
C. Bargmann and H. Horvitz (1991)
Science 251, 1243-1246
   Abstract »    PDF »
Neurosciences: an integrative discipline.
S. Snyder (1984)
Science 225, 1255-1257
   PDF »
Cell biology of synaptic plasticity.
C. Cotman and M Nieto-Sampedro (1984)
Science 225, 1287-1294
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)