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Science 14 September 1984:
Vol. 225. no. 4667, pp. 1170 - 1172
DOI: 10.1126/science.6089343
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Articles

Science, Vol 225, Issue 4667, 1170-1172
Copyright © 1984 by American Association for the Advancement of Science

articles

Insulin-mediated regulation of neuronal maturation

DG Puro and E Agardh

Exposure to insulin increased stimulus-evoked transmission at synapses formed in culture by cholinergic retinal neurons derived from fetal rats. This effect occurred at physiological concentrations and was long lasting. The findings support the hypothesis that insulin may serve as a developmental signal to regulate the emergence of effective neurotransmission across nascent synapses.


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