Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Science 14 September 1984:
Vol. 225. no. 4667, pp. 1168 - 1170
DOI: 10.1126/science.6474172

Articles

Science, Vol 225, Issue 4667, 1168-1170
Copyright © 1984 by American Association for the Advancement of Science


articles

Alzheimer's disease: cell-specific pathology isolates the hippocampal formation

BT Hyman, GW Van Hoesen, AR Damasio, and CL Barnes

Examination of temporal lobe structures from Alzheimer patients reveals a specific cellular pattern of pathology of the subiculum of the hippocampal formation and layers II and IV of the entorhinal cortex. The affected cells are precisely those that interconnect the hippocampal formation with the association cortices, basal forebrain, thalamus, and hypothalamus, structures crucial to memory. This focal pattern of pathology isolates the hippocampal formation from much of its input and output and probably contributes to the memory disorder in Alzheimer patients.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Validity of the Severe Impairment Battery Short Version.
J F M de Jonghe, R B Wetzels, A Mulders, S U Zuidema, and R T C M Koopmans (2009)
J. Neurol. Neurosurg. Psychiatry 80, 954-959
   Abstract »    Full Text »    PDF »
Modulation of GABAergic Transmission by Muscarinic Receptors in the Entorhinal Cortex of Juvenile Rats.
Z. Xiao, P.-Y. Deng, C. Yang, and S. Lei (2009)
J Neurophysiol 102, 659-669
   Abstract »    Full Text »    PDF »
Memory performance is related to amyloid and tau pathology in the hippocampus.
C Reitz, L Honig, J P Vonsattel, M-X Tang, and R Mayeux (2009)
J. Neurol. Neurosurg. Psychiatry 80, 715-721
   Abstract »    Full Text »    PDF »
Noradrenergic Depression of Neuronal Excitability in the Entorhinal Cortex via Activation of TREK-2 K+ Channels.
Z. Xiao, P.-Y. Deng, L. Rojanathammanee, C. Yang, L. Grisanti, K. Permpoonputtana, D. Weinshenker, V. A. Doze, J. E. Porter, and S. Lei (2009)
J. Biol. Chem. 284, 10980-10991
   Abstract »    Full Text »    PDF »
Temporoparietal MR Imaging Measures of Atrophy in Subjects with Mild Cognitive Impairment That Predict Subsequent Diagnosis of Alzheimer Disease.
R.S. Desikan, H.J. Cabral, B. Fischl, C.R.G. Guttmann, D. Blacker, B.T. Hyman, M.S. Albert, and R.J. Killiany (2009)
AJNR Am. J. Neuroradiol. 30, 532-538
   Abstract »    Full Text »    PDF »
The Cortical Signature of Alzheimer's Disease: Regionally Specific Cortical Thinning Relates to Symptom Severity in Very Mild to Mild AD Dementia and is Detectable in Asymptomatic Amyloid-Positive Individuals.
B. C. Dickerson, A. Bakkour, D. H. Salat, E. Feczko, J. Pacheco, D. N. Greve, F. Grodstein, C. I. Wright, D. Blacker, H. D. Rosas, et al. (2009)
Cereb Cortex 19, 497-510
   Abstract »    Full Text »    PDF »
Mapping local hippocampal changes in Alzheimer's disease and normal ageing with MRI at 3 Tesla.
G. B. Frisoni, R. Ganzola, E. Canu, U. Rub, F. B. Pizzini, F. Alessandrini, G. Zoccatelli, A. Beltramello, C. Caltagirone, and P. M. Thompson (2008)
Brain 131, 3266-3276
   Abstract »    Full Text »    PDF »
Amyloid precursor protein-induced axonopathies are independent of amyloid-{beta} peptides.
G. B. Stokin, A. Almenar-Queralt, S. Gunawardena, E. M. Rodrigues, T. Falzone, J. Kim, C. Lillo, S. L. Mount, E. A. Roberts, E. McGowan, et al. (2008)
Hum. Mol. Genet. 17, 3474-3486
   Abstract »    Full Text »    PDF »
Relationships between Hippocampal Atrophy, White Matter Disruption, and Gray Matter Hypometabolism in Alzheimer's Disease.
N. Villain, B. Desgranges, F. Viader, V. de la Sayette, F. Mezenge, B. Landeau, J.-C. Baron, F. Eustache, and G. Chetelat (2008)
J. Neurosci. 28, 6174-6181
   Abstract »    Full Text »    PDF »
Learning and Generalization Tasks Predict Short-Term Cognitive Outcome in Nondemented Elderly.
C. E. Myers, A. Kluger, J. Golomb, M. A. Gluck, and S. Ferris (2008)
J Geriatr Psychiatry Neurol 21, 93-103
   Abstract »    PDF »
Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: a reference data set.
W. S. Liang, T. Dunckley, T. G. Beach, A. Grover, D. Mastroeni, K. Ramsey, R. J. Caselli, W. A. Kukull, D. McKeel, J. C. Morris, et al. (2008)
Physiol Genomics 33, 240-256
   Abstract »    Full Text »    PDF »
Adrenergic Facilitation of GABAergic Transmission in Rat Entorhinal Cortex.
S. Lei, P.-Y. Deng, J. E. Porter, and H.-S. Shin (2007)
J Neurophysiol 98, 2868-2877
   Abstract »    Full Text »    PDF »
Impaired Spine Stability Underlies Plaque-Related Spine Loss in an Alzheimer's Disease Mouse Model.
T. L. Spires-Jones, M. Meyer-Luehmann, J. D. Osetek, P. B. Jones, E. A. Stern, B. J. Bacskai, and B. T. Hyman (2007)
Am. J. Pathol. 171, 1304-1311
   Abstract »    Full Text »    PDF »
Effects of Alzheimer's Disease on Different Cortical Layers: The Role of Intrinsic Differences in A{beta} Susceptibility.
R. R. Romito-DiGiacomo, H. Menegay, S. A. Cicero, and K. Herrup (2007)
J. Neurosci. 27, 8496-8504
   Abstract »    Full Text »    PDF »
Olfactory Identification and Incidence of Mild Cognitive Impairment in Older Age.
R. S. Wilson, J. A. Schneider, S. E. Arnold, Y. Tang, P. A. Boyle, and D. A. Bennett (2007)
Arch Gen Psychiatry 64, 802-808
   Abstract »    Full Text »    PDF »
State-Dependent Modulation of Amygdala Inputs by Dopamine-Induced Enhancement of Sodium Currents in Layer V Entorhinal Cortex.
J. A. Rosenkranz and D. Johnston (2007)
J. Neurosci. 27, 7054-7069
   Abstract »    Full Text »    PDF »
Neuropsychological Measures in Normal Individuals That Predict Subsequent Cognitive Decline.
D. Blacker, H. Lee, A. Muzikansky, E. C. Martin, R. Tanzi, J. J. McArdle, M. Moss, and M. Albert (2007)
Arch Neurol 64, 862-871
   Abstract »    Full Text »    PDF »
Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brain.
W. S. Liang, T. Dunckley, T. G. Beach, A. Grover, D. Mastroeni, D. G. Walker, R. J. Caselli, W. A. Kukull, D. McKeel, J. C. Morris, et al. (2007)
Physiol Genomics 28, 311-322
   Abstract »    Full Text »    PDF »
Hippocampal Sulcus Width and Cavities: Comparison Between Patients with Alzheimer Disease and Nondemented Elderly Subjects.
A.J. Bastos-Leite, J.H. van Waesberghe, A.L. Oen, W.M. van der Flier, P. Scheltens, and F. Barkhof (2006)
AJNR Am. J. Neuroradiol. 27, 2141-2145
   Abstract »    Full Text »    PDF »
Alzheimer's centennial legacy: origins, landmarks and the current status of knowledge concerning cognitive aspects..
J. R. Hodges (2006)
Brain 129, 2811-2822
   Abstract »    Full Text »    PDF »
Alterations in Memory Networks in Mild Cognitive Impairment and Alzheimer's Disease: An Independent Component Analysis.
K. A. Celone, V. D. Calhoun, B. C. Dickerson, A. Atri, E. F. Chua, S. L. Miller, K. DePeau, D. M. Rentz, D. J. Selkoe, D. Blacker, et al. (2006)
J. Neurosci. 26, 10222-10231
   Abstract »    Full Text »    PDF »
Quantitative MR Imaging in Alzheimer Disease.
A. Ramani, J. H. Jensen, and J. A. Helpern (2006)
Radiology 241, 26-44
   Abstract »    Full Text »    PDF »
Hippocampal disconnection contributes to memory dysfunction in individuals at risk for Alzheimer's disease.
T. R. Stoub, L. deToledo-Morrell, G. T. Stebbins, S. Leurgans, D. A. Bennett, and R. C. Shah (2006)
PNAS 103, 10041-10045
   Abstract »    Full Text »    PDF »
Familial risk for Alzheimer's disease alters fMRI activation patterns.
S. S. Bassett, D. M. Yousem, C. Cristinzio, I. Kusevic, M. A. Yassa, B. S. Caffo, and S. L. Zeger (2006)
Brain 129, 1229-1239
   Abstract »    Full Text »    PDF »
Region-specific Dissociation of Neuronal Loss and Neurofibrillary Pathology in a Mouse Model of Tauopathy.
T. L. Spires, J. D. Orne, K. SantaCruz, R. Pitstick, G. A. Carlson, K. H. Ashe, and B. T. Hyman (2006)
Am. J. Pathol. 168, 1598-1607
   Abstract »    Full Text »    PDF »
Dopaminergic regulation of neuronal excitability through modulation of Ih in layer V entorhinal cortex..
J. A. Rosenkranz and D. Johnston (2006)
J. Neurosci. 26, 3229-3244
   Abstract »    Full Text »    PDF »
Serotonin 1A receptors in the living brain of Alzheimer's disease patients.
V. Kepe, J. R. Barrio, S.-C. Huang, L. Ercoli, P. Siddarth, K. Shoghi-Jadid, G. M. Cole, N. Satyamurthy, J. L. Cummings, G. W. Small, et al. (2006)
PNAS 103, 702-707
   Abstract »    Full Text »    PDF »
Expression of a Familial Alzheimer's Disease-Linked Presenilin-1 Variant Enhances Perforant Pathway Lesion-Induced Neuronal Loss in the Entorhinal Cortex.
O. Lazarov, L. D. Peterson, D. A. Peterson, and S. S. Sisodia (2006)
J. Neurosci. 26, 429-434
   Abstract »    Full Text »    PDF »
Neuroanatomy/pathology and the interplay of neurotransmitters in moderate to severe Alzheimer disease.
P. T. Francis (2005)
Neurology 65, S5-S9
   Full Text »
Implicit memory and Alzheimer's disease neuropathology.
D. A. Fleischman, R. S. Wilson, J. D. E. Gabrieli, J. A. Schneider, J. L. Bienias, and D. A. Bennett (2005)
Brain 128, 2006-2015
   Abstract »    Full Text »    PDF »
Molecular, Structural, and Functional Characterization of Alzheimer's Disease: Evidence for a Relationship between Default Activity, Amyloid, and Memory.
R. L. Buckner, A. Z. Snyder, B. J. Shannon, G. LaRossa, R. Sachs, A. F. Fotenos, Y. I. Sheline, W. E. Klunk, C. A. Mathis, J. C. Morris, et al. (2005)
J. Neurosci. 25, 7709-7717
   Abstract »    Full Text »    PDF »
{beta}1 Adrenergic Receptor-Mediated Enhancement of Hippocampal CA3 Network Activity.
C. W. D. Jurgens, K. E. Rau, C. A. Knudson, J. D. King, P. A. Carr, J. E. Porter, and V. A. Doze (2005)
J. Pharmacol. Exp. Ther. 314, 552-560
   Abstract »    Full Text »    PDF »
Sex, Hormones, and Alzheimer's Disease.
L. W. Baum (2005)
J. Gerontol. A Biol. Sci. Med. Sci. 60, 736-743
   Abstract »    Full Text »    PDF »
Early A{beta} accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain.
M. Ingelsson, H. Fukumoto, K. L. Newell, J. H. Growdon, E. T. Hedley-Whyte, M. P. Frosch, M. S. Albert, B. T. Hyman, and M. C. Irizarry (2004)
Neurology 62, 925-931
   Abstract »    Full Text »    PDF »
Shrinkage of the Entorhinal Cortex over Five Years Predicts Memory Performance in Healthy Adults.
K. M. Rodrigue and N. Raz (2004)
J. Neurosci. 24, 956-963
   Abstract »    Full Text »    PDF »
Gamma Oscillations Induced by Kainate Receptor Activation in the Entorhinal Cortex In Vitro.
M. O. Cunningham, C. H. Davies, E. H. Buhl, N. Kopell, and M. A. Whittington (2003)
J. Neurosci. 23, 9761-9769
   Abstract »    Full Text »    PDF »
Neuropsychological stydy of familial Alzheimer's disease caused by mutation E280A in the presenilin 1 gene.
J. C. A. Lasprilla, J. Iglesias, and F. Lopera (2003)
American Journal of Alzheimer's Disease and Other Dementias 18, 137-146
   Abstract »    PDF »
Amyloid deposition in the hippocampus and entorhinal cortex: Quantitative analysis of a transgenic mouse model.
J. F. Reilly, D. Games, R. E. Rydel, S. Freedman, D. Schenk, W. G. Young, J. H. Morrison, and F. E. Bloom (2003)
PNAS 100, 4837-4842
   Abstract »    Full Text »    PDF »
Neuronal Cell Death Is Preceded by Cell Cycle Events at All Stages of Alzheimer's Disease.
Y. Yang, E. J. Mufson, and K. Herrup (2003)
J. Neurosci. 23, 2557-2563
   Abstract »    Full Text »    PDF »
Dentate gyrus volume is reduced before onset of plaque formation in PDAPP mice: A magnetic resonance microscopy and stereologic analysis.
J. M. Redwine, B. Kosofsky, R. E. Jacobs, D. Games, J. F. Reilly, J. H. Morrison, W. G. Young, and F. E. Bloom (2003)
PNAS 100, 1381-1386
   Abstract »    Full Text »    PDF »
Abnormal verbal event related potentials in mild cognitive impairment and incipient Alzheimer's disease.
J M Olichney, S K Morris, C Ochoa, D P Salmon, L J Thal, M Kutas, and V J Iragui (2002)
J. Neurol. Neurosurg. Psychiatry 73, 377-384
   Abstract »    Full Text »    PDF »
Overexpression of hAPPswe Impairs Rewarded Alternation and Contextual Fear Conditioning in a Transgenic Mouse Model of Alzheimer's Disease.
K. A. Corcoran, Y. Lu, R. S. Turner, and S. Maren (2002)
Learn. Mem. 9, 243-252
   Abstract »    Full Text »    PDF »
Hippocampal Atrophy Disrupts Transfer Generalization in Nondemented Elderly.
C. E. Myers, A. Kluger, J. Golomb, S. Ferris, M. J. de Leon, G. Schnirman, and M. A. Gluck (2002)
J Geriatr Psychiatry Neurol 15, 82-90
   Abstract »    PDF »
MRI measures of entorhinal cortex vs hippocampus in preclinical AD.
R. J. Killiany, B. T. Hyman, T. Gomez-Isla, M. B. Moss, R. Kikinis, F. Jolesz, R. Tanzi, K. Jones, and M. S. Albert (2002)
Neurology 58, 1188-1196
   Abstract »    Full Text »    PDF »
Imaging the progression of Alzheimer pathology through the brain.
A. D. Smith (2002)
PNAS 99, 4135-4137
   Full Text »    PDF »
Relation of Medial Temporal Lobe Volumes to Age and Memory Function in Nondemented Adults With Down's Syndrome: Implications for the Prodromal Phase of Alzheimer's Disease.
J. S. Krasuski, G. E. Alexander, B. Horwitz, S. I. Rapoport, and M. B. Schapiro (2002)
Am J Psychiatry 159, 74-81
   Abstract »    Full Text »    PDF »
Effect of apolipoprotein E genotype on hippocampal volume loss in aging healthy women.
R. M. Cohen, C. Small, F. Lalonde, J. Friz, and T. Sunderland (2001)
Neurology 57, 2223-2228
   Abstract »    Full Text »    PDF »
Presenilin Binding Protein Is Associated with Neurofibrillary Alterations in Alzheimer's Disease and Stimulates Tau Phosphorylation.
Q. Chen, H. Yoshida, D. Schubert, P. Maher, M. Mallory, and E. Masliah (2001)
Am. J. Pathol. 159, 1597-1602
   Abstract »    Full Text »    PDF »
Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy in Dementias.
Y.-Y. Hsu, A.-T. Du, N. Schuff, and M. W. Weiner (2001)
J Geriatr Psychiatry Neurol 14, 145-166
   Abstract »    PDF »
Selective Preservation and Degeneration Within the Prefrontal Cortex in Aging and Alzheimer Disease.
D. H. Salat, J. A. Kaye, and J. S. Janowsky (2001)
Arch Neurol 58, 1403-1408
   Abstract »    Full Text »    PDF »
Generation of Aggregated {beta}-Amyloid in the Rat Hippocampus Impairs Synaptic Transmission and Plasticity and Causes Memory Deficits.
A. Stephan, S. Laroche, and S. Davis (2001)
J. Neurosci. 21, 5703-5714
   Abstract »    Full Text »    PDF »
Presenilin-1-associated abnormalities in regional cerebral perfusion.
K.A. Johnson, F. Lopera, K. Jones, A. Becker, R. Sperling, J. Hilson, J. Londono, I. Siegert, M. Arcos, S. Moreno, et al. (2001)
Neurology 56, 1545-1551
   Abstract »    Full Text »    PDF »
Action Potential Bursting in Subicular Pyramidal Neurons Is Driven by a Calcium Tail Current.
H.-y. Jung, N. P. Staff, and N. Spruston (2001)
J. Neurosci. 21, 3312-3321
   Abstract »    Full Text »    PDF »
Rating of Different Olfactory Judgements in Alzheimer's Disease.
J.P. Royet, B. Croisile, R. Williamson-Vasta, O. Hibert, D. Serclerat, and J. Guerin (2001)
Chem Senses 26, 409-417
   Abstract »    Full Text »    PDF »
Worsening of Post-Traumatic Stress Disorder Symptoms with Cognitive Decline: Case Series.
D. Mittal, R. Torres, A. Abashidze, and N. Jimerson (2001)
J Geriatr Psychiatry Neurol 14, 17-20
   Abstract »    PDF »
Frontotemporal dementia with ubiquitinated inclusions: A case study of the regional distribution of hippocampal pathology.
B. Mehring, J. C.Y. Lin, D. Wilson, and C. F. Lippa (2000)
American Journal of Alzheimer's Disease and Other Dementias 15, 277-283
   Abstract »    PDF »
Magnetization Transfer Measurements of the Hippocampus in Patients with Alzheimer's Disease, Vascular Dementia, and Other Types of Dementia.
H. Hanyu, T. Asano, T. Iwamoto, M. Takasaki, H. Shindo, and K. Abe (2000)
AJNR Am. J. Neuroradiol. 21, 1235-1242
   Abstract »    Full Text »    PDF »
Orbitofrontal Cortex Pathology in Alzheimer's Disease.
G. W. Van Hoesen, J. Parvizi, and C.-C. Chu (2000)
Cereb Cortex 10, 243-251
   Abstract »    Full Text »    PDF »
Phosphorylation of Microtubule-associated Protein Tau Is Regulated by Protein Phosphatase 2A in Mammalian Brain. IMPLICATIONS FOR NEUROFIBRILLARY DEGENERATION IN ALZHEIMER'S DISEASE.
C.-X. Gong, T. Lidsky, J. Wegiel, L. Zuck, I. Grundke-Iqbal, and K. Iqbal (2000)
J. Biol. Chem. 275, 5535-5544
   Abstract »    Full Text »    PDF »
Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients.
D. Lütjohann, A. Papassotiropoulos, I. Björkhem, S. Locatelli, M. Bagli, R. D. Oehring, U. Schlegel, F. Jessen, M. L. Rao, K. von Bergmann, et al. (2000)
J. Lipid Res. 41, 195-198
   Abstract »    Full Text »
Cerebral Amyloid Induces Aberrant Axonal Sprouting and Ectopic Terminal Formation in Amyloid Precursor Protein Transgenic Mice.
A. L. Phinney, T. Deller, M. Stalder, M. E. Calhoun, M. Frotscher, B. Sommer, M. Staufenbiel, and M. Jucker (1999)
J. Neurosci. 19, 8552-8559
   Abstract »    Full Text »    PDF »
Preclinical memory decline in cognitively normal apolipoprotein E-{epsilon}4 homozygotes.
R. J. Caselli, N. R. Graff-Radford, E. M. Reiman, A. Weaver, D. Osborne, J. Lucas, A. Uecker, and S. N. Thibodeau (1999)
Neurology 53, 201
   Abstract »    Full Text »
Challenging the Cholinergic Hypothesis in Alzheimer Disease.
P. Davies (1999)
JAMA 281, 1433-1434
   Full Text »    PDF »
Attention and executive deficits in Alzheimer's disease: A critical review.
R. J. Perry and J. R. Hodges (1999)
Brain 122, 383-404
   Abstract »    Full Text »    PDF »
Amygdalar Volume and Emotional Memory in Alzheimer's Disease.
E. Mori, M. Ikeda, N. Hirono, H. Kitagaki, T. Imamura, and T. Shimomura (1999)
Am J Psychiatry 156, 216-222
   Abstract »    Full Text »
Successful Verbal Encoding into Episodic Memory Engages the Posterior Hippocampus: A Parametrically Analyzed Functional Magnetic Resonance Imaging Study.
G. Fernandez, H. Weyerts, M. Schrader-Bolsche, I. Tendolkar, H. G. O. M. Smid, C. Tempelmann, H. Hinrichs, H. Scheich, C. E. Elger, G. R. Mangun, et al. (1998)
J. Neurosci. 18, 1841-1847
   Abstract »    Full Text »    PDF »
Gamma Oscillations in the Entorhinal Cortex of the Freely Behaving Rat.
J. J. Chrobak and G. Buzsaki (1998)
J. Neurosci. 18, 388-398
   Abstract »    Full Text »    PDF »
Life and Death of Neurons in the Aging Brain.
J. H. Morrison and P. R. Hof (1997)
Science 278, 412-419
   Abstract »    Full Text »
Medial temporal structures relate to memory impairment in Alzheimer's disease: an MRI volumetric study.
E. Mori, Y. Yoneda, H. Yamashita, N. Hirono, M. Ikeda, and A. Yamadori (1997)
J. Neurol. Neurosurg. Psychiatry 63, 214-221
   Abstract »    Full Text »    PDF »
Olfactory Dysfunction for Pyridine and Dementia Progression in Alzheimer Disease.
S. Nordin, O. Almkvist, B. Berglund, and L.-O. Wahlund (1997)
Arch Neurol 54, 993-998
   Abstract »    PDF »
Differential Subcellular Regulation of NMDAR1 Protein and mRNA in Dendrites of Dentate Gyrus Granule Cells after Perforant Path Transection.
A. H. Gazzaley, D. L. Benson, G. W. Huntley, and J. H. Morrison (1997)
J. Neurosci. 17, 2006-2017
   Abstract »    Full Text »    PDF »
In situ hybridization analysis of presenilin 1 mRNA in Alzheimer disease and in lesioned rat brain.
K. Page, R. Hollister, R. E. Tanzi, and B. T. Hyman (1996)
PNAS 93, 14020-14024
   Abstract »    Full Text »    PDF »
Estrogen Replacement Therapy and Risk of Alzheimer Disease.
A. Paganini-Hill and V. W. Henderson (1996)
Arch Intern Med 156, 2213-2217
   Abstract »    PDF »
Age at Onset and Pattern of Neuropsychological Impairment in Mild Early-Stage Alzheimer Disease: A Study of a Community-Based Population.
W. Reid, G. Broe, H. Creasey, D. Grayson, E. McCusker, H. Bennett, W. Longley, and M. R. Sulway (1996)
Arch Neurol 53, 1056-1061
   Abstract »    PDF »
Comparison of Neurodegenerative Pathology in Transgenic Mice Overexpressing V717F beta -Amyloid Precursor Protein and Alzheimer's Disease.
E. Masliah, A. Sisk, M. Mallory, L. Mucke, D. Schenk, and D. Games (1996)
J. Neurosci. 16, 5795-5811
   Abstract »    Full Text »    PDF »
Frontal Behavioral Syndromes in Cortical and Subcortical Dementia.
J. S. Paulsen, J. C. Stout, J. DeLaPena, R. Romero, Z. Tawfik-Reedy, M. R. Swenson, J. Grace, P. F. Malloy, and B. Hospital (1996)
Assessment 3, 327-337
   Abstract »
{blacksquare} REVIEW : Glutamate Receptors: Emerging Links Between Subunit Proteins and Specific Excitatory Circuits in Primate Hippocampus and Neocortex.
J. H. Morrison, S. J. Siegel, A. H. Gazzaley, and G. W. Huntley (1996)
Neuroscientist 2, 272-283
   Abstract »    PDF »
Profound Loss of Layer II Entorhinal Cortex Neurons Occurs in Very Mild Alzheimer''s Disease.
T. Gomez-Isla, J. L. Price, D. W. McKeel Jr., J. C. Morris, J. H. Growdon, and B. T. Hyman (1996)
J. Neurosci. 16, 4491-4500
   Abstract »    Full Text »    PDF »
Contingent Vulnerability of Entorhinal Parvalbumin-Containing Neurons in Alzheimer''s Disease.
A. Solodkin, S. D. Veldhuizen, and G. W. Van Hoesen (1996)
J. Neurosci. 16, 3311-3321
   Abstract »    Full Text »    PDF »
Neocortical Neurofibrillary Tangles Correlate With Dementia Severity in Alzheimer's Disease.
L. M. Bierer, P. R. Hof, D. P. Purohit, L. Carlin, J. Schmeidler, K. L. Davis, and D. P. Perl (1995)
Arch Neurol 52, 81-88
   Abstract »    PDF »
Estrogen Replacement Therapy in Older Women: Comparisons Between Alzheimer's Disease Cases and Nondemented Control Subjects.
V. W. Henderson, A. Paganini-Hill, C. K. Emanuel, M. E. Dunn, and J. G. Buckwalter (1994)
Arch Neurol 51, 896-900
   Abstract »    PDF »
Lack of Difference in Brain Hyperintensities Between Patients With Early Alzheimer's Disease and Control Subjects.
T. Erkinjuntti, F. Gao, D. H. Lee, M. Eliasziw, H. Merskey, and V. C. Hachinski (1994)
Arch Neurol 51, 260-268
   Abstract »    PDF »
Evidence of Subtypes of Alzheimer's Disease and Implications for Etiology.
W. Bondareff, C. Q. Mountjoy, C. M. Wischik, D. L. Hauser, L. D. LaBree, and M. Roth (1993)
Arch Gen Psychiatry 50, 350-356
   Abstract »    PDF »
Temporal Lobe Atrophy on Magnetic Resonance Imaging in the Diagnosis of Early Alzheimer's Disease.
T. Erkinjuntti, D. H. Lee, F. Gao, R. Steenhuis, M. Eliasziw, R. Fry, H. Merskey, and V. C. Hachinski (1993)
Arch Neurol 50, 305-310
   Abstract »    PDF »
Topography of Cross-sectional and Longitudinal Glucose Metabolic Deficits in Alzheimer's Disease: Pathophysiologic Implications.
G. S. Smith, M. J. de Leon, A. E. George, A. Kluger, N. D. Volkow, T. McRae, J. Golomb, S. H. Ferris, B. Reisberg, J. Ciaravino, et al. (1992)
Arch Neurol 49, 1142-1150
   Abstract »    PDF »
Detection and Staging of Dementia in Alzheimer's Disease: Use of the Neuropsychological Measures Developed for the Consortium to Establish a Registry for Alzheimer's Disease.
K. A. Welsh, N. Butters, J. P. Hughes, R. C. Mohs, and A. Heyman (1992)
Arch Neurol 49, 448-452
   Abstract »    PDF »
Quantitative Changes in Mesial Temporal Volume, Regional Cerebral Blood Flow, and Cognition in Alzheimer's Disease.
G. D. Pearlson, G. J. Harris, R. E. Powers, P. E. Barta, E. E. Camargo, G. A. Chase, J. T. Noga, and L. E. Tune (1992)
Arch Gen Psychiatry 49, 402-408
   Abstract »    PDF »
The medial temporal lobe memory system.
L. Squire and S Zola-Morgan (1991)
Science 253, 1380-1386
   Abstract »    PDF »
Temporal and Hippocampal Metabolic Rate During an Olfactory Memory Task Assessed by Positron Emission Tomography in Patients With Dementia of the Alzheimer Type and Controls: Preliminary Studies.
M. S. Buchsbaum, J. P. Kesslak, G. Lynch, H. Chui, J. Wu, N. Sicotte, E. Hazlett, E. Teng, and C. W. Cotman (1991)
Arch Gen Psychiatry 48, 840-847
   Abstract »    PDF »
Some Cytoarchitectural Abnormalities of the Entorhinal Cortex in Schizophrenia.
s. E. Arnold, B. T. Hyman, G. W. Van Hoesen, and A. R. Damasio (1991)
Arch Gen Psychiatry 48, 625-632
   Abstract »    PDF »
Differentiation of Alzheimer's Disease and Huntington's Disease With the Dementia Rating Scale.
D. P. Salmon, P. F. Kwo-on-Yuen, W. C. Heindel, N. Butters, and L. J. Thal (1989)
Arch Neurol 46, 1204-1208
   Abstract »    PDF »
Dementia: A Review Emphasizing Clinicopathologic Correlation and Brain-Behavior Relationships.
H. C. Chui (1989)
Arch Neurol 46, 806-814
   Abstract »    PDF »
Commissural Connections and Symmetry of Degeneration in Alzheimer's Disease.
S. Demeter, D. L. Rosene, and G. W. Van Hoesen (1989)
Arch Neurol 46, 723-724
   Abstract »    PDF »
Amyloid beta protein enhances the survival of hippocampal neurons in vitro.
J. Whitson, D. Selkoe, and C. Cotman (1989)
Science 243, 1488-1490
   Abstract »    PDF »
A Verbal Memory Test With High Predictive Accuracy for Dementia of the Alzheimer Type.
D. S. Knopman and S. Ryberg (1989)
Arch Neurol 46, 141-145
   Abstract »    PDF »
Alzheimer Disease: Clinical and Biological Heterogeneity.
R. P. Friedland, E. Koss, J. V. Haxby, C. L. Grady, J. Luxenberg, M. B. Schapiro, and J. Kaye (1988)
Ann Intern Med 109, 298-311
   Abstract »    PDF »
Research in Alzheimer's disease: A progress report.
M. B. Moss (1988)
American Journal of Alzheimer's Disease and Other Dementias 3, 10-16
   PDF »



To Advertise     Find Products


Science. ISSN 0036-8075 (print), 1095-9203 (online)