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Science 7 September 1984:
Vol. 225. no. 4666, pp. 1041 - 1043
DOI: 10.1126/science.6089339
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Articles

Science, Vol 225, Issue 4666, 1041-1043
Copyright © 1984 by American Association for the Advancement of Science

articles

Isolation, characterization, and chromosome assignment of mouse N-ras gene from carcinogen-induced thymic lymphoma

I Guerrero, A Villasante, P D'Eustachio, and A Pellicer

Treatment of mice with the carcinogen N-methylnitrosourea results in the development of thymic lymphomas with frequent involvement of the N-ras oncogene. The activated mouse N-ras gene was isolated from one of these lymphomas and, by transformation in concert with restriction digestion, a map of the gene was prepared and its approximate boundaries were determined. By means of somatic cell hybrids the normal N-ras gene was found to be unlinked to other members of the ras gene family.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)