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Science 7 September 1984:
Vol. 225. no. 4666, pp. 1034 - 1036
DOI: 10.1126/science.6089338
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Articles

Science, Vol 225, Issue 4666, 1034-1036
Copyright © 1984 by American Association for the Advancement of Science

articles

Small cell carcinoma of the lung: macrophage-specific antigens suggest hemopoietic stem cell origin

MR Ruff and CB Pert

Four surface antigens previously recognized only in macrophages are present on human small cell lung carcinoma cells and tumors. Cancerous cells may arise from macrophage precursors in bone marrow, and these precursors migrate to lung to participate in the repair of damaged tissue produced by continuous heavy smoking. The characteristic presence of neuropeptides such as bombesin in small cell carcinoma, when considered along with these findings, presents new possibilities for the role of such peptides in nervous, endocrine, and immune system function.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Lung Cells Transplanted to Irradiated Recipients Generate Lymphohematopoietic Progeny.
S. Abe, G. Lauby, C. Boyer, L. Manouilova, S. I. Rennard, and J. G. Sharp (2004)
Am. J. Respir. Cell Mol. Biol. 30, 491-499
   Abstract »    Full Text »    PDF »
The Dispersed Neuroendocrine Cells: The Structure, Function, Regulation and Effects of Xenobiotics on this System.
A. S. Tischler (1989)
Toxicol Pathol 17, 307-316
   Abstract »    PDF »
Benzodiazepine receptor-mediated chemotaxis of human monocytes.
M. Ruff, C. Pert, R. Weber, L. Wahl, S. Wahl, and S. Paul (1985)
Science 229, 1281-1283
   Abstract »    PDF »
Origin of human small cell lung cancer.
A. Gazdar, P. Bunn Jr, J. Minna, and S. Baylin (1985)
Science 229, 679-680
   PDF »
Origin of Human Small Cell Lung Cancer.
M. R. RUFF and C. B. PERT (1985)
Science 229, 680
   PDF »


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