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Science 7 September 1984:
Vol. 225. no. 4666, pp. 1032 - 1034
DOI: 10.1126/science.6474163
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Articles

Science, Vol 225, Issue 4666, 1032-1034
Copyright © 1984 by American Association for the Advancement of Science

articles

Inhibition of human estrogen synthetase (aromatase) by flavones

JT Kellis Jr and LE Vickery

Several naturally occurring and synthetic flavones were found to inhibit the aromatization of androstenedione and testosterone to estrogens catalyzed by human placental and ovarian microsomes. These flavones include (in order of decreasing potency) 7,8-benzoflavone, chrysin, apigenin, flavone, flavanone, and quercetin; 5,6-benzoflavone was not inhibitory. 7,8-Benzoflavone and chrysin were potent competitive inhibitors and induced spectral changes in the aromatase cytochrome P-450 indicative of substrate displacement. Flavones may thus compete with steroids in their interaction with certain monooxygenases and thereby alter steroid hormone metabolism.


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