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Science 31 August 1984:
Vol. 225. no. 4665, pp. 949 - 951
DOI: 10.1126/science.6382608
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Articles

Science, Vol 225, Issue 4665, 949-951
Copyright © 1984 by American Association for the Advancement of Science

articles

Mating and pregnancy can occur in genetically hypogonadal mice with preoptic area brain grafts

MJ Gibson, DT Krieger, HM Charlton, EA Zimmerman, AJ Silverman, and MJ Perlow

Adult female hypogonadal mice, in whom hypogonadism is secondary to a genetic deficiency in hypothalamic gonadotropin-releasing hormone (GnRH), are infertile. Mating, pregnancy, and delivery of healthy litters were achieved after transplantation of normal fetal preoptic area tissue, a major site of GnRH-containing cell bodies, into the third ventricle of adult female hypogonadal mice. Immunocytochemistry revealed GnRH-containing neurons in the grafts and GnRH-containing processes extending to the lateral median eminence of the host brains.


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