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Science 31 August 1984:
Vol. 225. no. 4665, pp. 947 - 949
DOI: 10.1126/science.6206567
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Articles

Science, Vol 225, Issue 4665, 947-949
Copyright © 1984 by American Association for the Advancement of Science

articles

Alzheimer's disease brain: alterations in RNA levels and in a ribonuclease-inhibitor complex

EM Sajdel-Sulkowska and CA Marotta

A macromolecular alteration occurs at the posttranscriptional level in the Alzheimer's disease (AD) brain. Compared with age-matched controls, total cellular RNA and polyadenylated RNA were substantially reduced in the AD cortex with many neuritic plaques and neurofibrillary tangles. RNA changes are associated with a significant increase in alkaline ribonuclease activity due to an abnormality in the ribonuclease-inhibitor complex. The decrease in protein synthesis in the AD brain, previously observed in patients severely affected with AD, and in translation systems in vitro with AD cortical messenger RNA, may be partly related to an enzyme-inhibitor alteration that affects RNA levels and activity. Decreased protein synthesis therefore may contribute to the characteristic decline in certain neurotransmitter enzymes and to the loss of neurons in the AD brain.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Ribosome Dysfunction Is an Early Event in Alzheimer's Disease.
Q. Ding, W. R. Markesbery, Q. Chen, F. Li, and J. N. Keller (2005)
J. Neurosci. 25, 9171-9175
   Abstract »    Full Text »    PDF »
Ribosomal RNA in Alzheimer Disease Is Oxidized by Bound Redox-active Iron.
K. Honda, M. A. Smith, X. Zhu, D. Baus, W. C. Merrick, A. M. Tartakoff, T. Hattier, P. L. Harris, S. L. Siedlak, H. Fujioka, et al. (2005)
J. Biol. Chem. 280, 20978-20986
   Abstract »    Full Text »    PDF »
Thiol-Disulfide Exchange of Ribonuclease Inhibitor Bound to Ribonuclease A.
M. Ferreras, J. G. Gavilanes, C. López-Otín, and J. M. García-Segura (1995)
J. Biol. Chem. 270, 28570-28578
   Abstract »    Full Text »    PDF »
Etiologic theories of Alzheimer's disease.
M. Schweber (1986)
American Journal of Alzheimer's Disease and Other Dementias 1, 24-31
   Abstract »    PDF »


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