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Science 31 August 1984:
Vol. 225. no. 4665, pp. 938 - 941
DOI: 10.1126/science.6474160
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Articles

Science, Vol 225, Issue 4665, 938-941
Copyright © 1984 by American Association for the Advancement of Science

articles

Scintigraphy of normal mouse ovaries with monoclonal antibodies to ZP-2, the major zona pellucida protein

IJ East, AM Keenan, SM Larson, and J Dean

The zona pellucida is an extracellular glycocalyx, made of three sulfated glycoproteins, that surrounds mammalian oocytes. Parenterally administered monoclonal antibodies specific for ZP-2, the most abundant zona protein, localize in the zona pellucida. When labeled with iodine-125, these monoclonal antibodies demonstrate a remarkably high target-to-nontarget tissue ratio and provide clear external radioimaging of ovarian tissue.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Progress and Promise of Molecular Imaging Probes in Oncologic Drug Development.
G. J. Kelloff, K. A. Krohn, S. M. Larson, R. Weissleder, D. A. Mankoff, J. M. Hoffman, J. M. Link, K. Z. Guyton, W. C. Eckelman, H. I. Scher, et al. (2005)
Clin. Cancer Res. 11, 7967-7985
   Abstract »    Full Text »    PDF »
Manipulating the genome to study reproduction: Mice with `humanized' zonae pellucidae.
Philip.E. Castle and J. Dean (1999)
Hum. Reprod. 14, 1927-1939
   Full Text »    PDF »
A Contraceptive Peptide Vaccine Targeting Sulfated Glycoprotein ZP2 of the Mouse Zona Pellucida.
W. Sun, Y. H. Lou, J. Dean, and K. S.K. Tung (1999)
Biol Reprod 60, 900-907
   Abstract »    Full Text »
Vaccination with a synthetic zona pellucida peptide produces long-term contraception in female mice.
S. Millar, S. Chamow, A. Baur, C Oliver, F Robey, and J Dean (1989)
Science 246, 935-938
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)