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Science 31 August 1984:
Vol. 225. no. 4665, pp. 927 - 930
DOI: 10.1126/science.6089333
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Articles

Science, Vol 225, Issue 4665, 927-930
Copyright © 1984 by American Association for the Advancement of Science

articles

Homology of genome of AIDS-associated virus with genomes of human T-cell leukemia viruses

SK Arya, RC Gallo, BH Hahn, GM Shaw, M Popovic, SZ Salahuddin, and F Wong-Staal

A T lymphotropic virus found in patients with the acquired immune deficiency syndrome (AIDS) or lymphadenopathy syndrome has been postulated to be the cause of AIDS. Immunological analysis of this retrovirus and its biological properties suggest that it is a member of the family of human T-lymphotropic retroviruses known as HTLV. Accordingly, it has been named HTLV-III. In the present report it is shown by nucleic acid hybridization that sequences of the genome of HTLV-III are homologous to the structural genes (gag, pol, and env) of both HTLV-I and HTLV-II and to a potential coding region called pX located between the env gene and the long terminal repeating sequence that is unique to the HTLV family of retroviruses.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
HTLV-I--associated B-cell CLL: indirect role for retrovirus in leukemogenesis.
D. Mann, P DeSantis, G Mark, A Pfeifer, M Newman, N Gibbs, M Popovic, M. Sarngadharan, R. Gallo, J Clark, et al. (1987)
Science 236, 1103-1106
   Abstract »    PDF »
Alterations in T4 (CD4) protein and mRNA synthesis in cells infected with HIV.
J. Hoxie, J. Alpers, J. Rackowski, K Huebner, B. Haggarty, A. Cedarbaum, and J. Reed (1986)
Science 234, 1123-1127
   Abstract »    PDF »
Infection With HTLV-III/LAV and Transfusion-Associated Acquired Immunodeficiency Syndrome: Serologic Evidence of an Association.
H. W. Jaffe, M. G. Sarngadharan, A. L. DeVico, L. Bruch, J. P. Getchell, V. S. Kalyanaraman, H. W. Haverkos, R. L. Stoneburner, R. C. Gallo, and J. W. Curran (1985)
JAMA 254, 770-773
   Abstract »    PDF »
Trans-activator gene of human T-lymphotropic virus type III (HTLV-III).
S. Arya, C Guo, S. Josephs, and F Wong-Staal (1985)
Science 229, 69-73
   Abstract »    PDF »
Virus envelope protein of HTLV-III represents major target antigen for antibodies in AIDS patients.
F Barin, M. McLane, J. Allan, T. Lee, J. Groopman, and M Essex (1985)
Science 228, 1094-1096
   Abstract »    PDF »
Expression in Escherichia coli of open reading frame gene segments of HTLV-III.
N. Chang, P. Chanda, A. Barone, S McKinney, D. Rhodes, S. Tam, C. Shearman, J Huang, T. Chang, R. Gallo, et al. (1985)
Science 228, 93-96
   Abstract »    PDF »
Nucleotide sequence and expression of an AIDS-associated retrovirus (ARV-2).
R Sanchez-Pescador, M. Power, P. Barr, K. Steimer, M. Stempien, S. Brown-Shimer, W. Gee, A Renard, A Randolph, J. Levy, et al. (1985)
Science 227, 484-492
   Abstract »    PDF »
Trans-acting transcriptional regulation of human T-cell leukemia virus type III long terminal repeat.
J Sodroski, C Rosen, F Wong-Staal, S. Salahuddin, M Popovic, S Arya, R. Gallo, and W. Haseltine (1985)
Science 227, 171-173
   Abstract »    PDF »
Sequence homology and morphologic similarity of HTLV-III and visna virus, a pathogenic lentivirus.
M. Gonda, F Wong-Staal, R. Gallo, J. Clements, O Narayan, and R. Gilden (1985)
Science 227, 173-177
   Abstract »    PDF »
Molecular characterization of human T-cell leukemia (lymphotropic) virus type III in the acquired immune deficiency syndrome.
G. Shaw, B. Hahn, S. Arya, J. Groopman, R. Gallo, and F Wong-Staal (1984)
Science 226, 1165-1171
   Abstract »    PDF »


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