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Science 24 August 1984:
Vol. 225. no. 4664, pp. 840 - 842
DOI: 10.1126/science.6206563

Articles

Science, Vol 225, Issue 4664, 840-842
Copyright © 1984 by American Association for the Advancement of Science


articles

Isolation of lymphocytopathic retroviruses from San Francisco patients with AIDS

JA Levy, AD Hoffman, SM Kramer, JA Landis, JM Shimabukuro, and LS Oshiro

Infectious retroviruses have been detected in 22 of 45 randomly selected patients with acquired immune deficiency syndrome (AIDS) and in other individuals from San Francisco. The AIDS-associated retroviruses (ARV) studied in detail had a type D morphology, Mg2+-dependent reverse transcriptase, and cytopathic effects on lymphocytes. The viruses can be propagated in an established adult human T cell line, HUT-78. They cross-react with antiserum to the lymphadenopathy-associated retrovirus isolated from AIDS patients in France. Antibodies to ARV were found in all 86 AIDS patients and in a high percentage of 88 other homosexual men in San Francisco. This observation indicates the widespread presence of these lymphocytopathic retroviruses and their close association with AIDS.


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   Abstract »    PDF »
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Ann Intern Med 103, 542-545
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Transient Antibody to Lymphadenopathy-Associated Virus/Human T-Lymphotropic Virus Type III and T-Lymphocyte Abnormalities in the Wife of a Man Who Developed the Acquired Immunodeficiency Syndrome.
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The epidemiology of AIDS: current status and future prospects.
J. Curran, W. Morgan, A. Hardy, H. Jaffe, W. Darrow, and W. Dowdle (1985)
Science 229, 1352-1357
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Transcription of novel open reading frames of AIDS retrovirus during infection of lymphocytes.
A. Rabson, D. Daugherty, S Venkatesan, K. Boulukos, S. Benn, T. Folks, P Feorino, and M. Martin (1985)
Science 229, 1388-1390
   Abstract »    PDF »



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