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Science 24 August 1984: Vol. 225. no. 4664, pp. 840 - 842 DOI: 10.1126/science.6206563
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Articles
Science, Vol 225, Issue 4664, 840-842
Copyright © 1984 by American Association for the Advancement of Science
Isolation of lymphocytopathic retroviruses from San Francisco patients with AIDS
JA Levy,
AD Hoffman,
SM Kramer,
JA Landis,
JM Shimabukuro,
and
LS Oshiro
Infectious retroviruses have been detected in 22 of 45 randomly selected patients with acquired immune deficiency syndrome (AIDS) and in other individuals from San Francisco. The AIDS-associated retroviruses (ARV) studied in detail had a type D morphology, Mg2+-dependent reverse transcriptase, and cytopathic effects on lymphocytes. The viruses can be propagated in an established adult human T cell line, HUT-78. They cross-react with antiserum to the lymphadenopathy-associated retrovirus isolated from AIDS patients in France. Antibodies to ARV were found in all 86 AIDS patients and in a high percentage of 88 other homosexual men in San Francisco. This observation indicates the widespread presence of these lymphocytopathic retroviruses and their close association with AIDS.
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- Primary Human T-Lymphotropic Virus Type III Infection.
- D. D. HO, M. G. SARNGADHARAN, L. RESNICK, F. DIMARZOVERONESE, T. R. ROTA, and M. S. HIRSCH (1985)
Ann Intern Med
103, 880-883
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- A new HTLV-III/LAV encoded antigen detected by antibodies from AIDS patients.
- J. Allan, J. Coligan, T. Lee, M. McLane, P. Kanki, J. Groopman, and M Essex (1985)
Science
230, 810-813
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- Epidemiology of Human T-Lymphotropic Virus Type III and the Risk of the Acquired Immunodeficiency Syndrome.
- W. A. BLATTNER, R. J. BIGGAR, S. H. WEISS, M. MELBYE, and J. J. GOEDERT (1985)
Ann Intern Med
103, 665-670
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- A Human T-Lymphotropic Retrovirus (HTLV-III) as the Cause of the Acquired Immunodeficiency Syndrome.
- R. C. GALLO and F. WONG-STAAL (1985)
Ann Intern Med
103, 679-689
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- Infection by the Retrovirus Associated with the Acquired Immunodeficiency Syndrome: Clinical, Biological, and Molecular Features.
- J. A. LEVY, L. S. KAMINSKY, W. J. W. MORROW, K. STEIMER, P. LUCIW, D. DINA, J. HOXIE, and L. OSHIRO (1985)
Ann Intern Med
103, 694-699
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- The Clinical Spectrum of the Acquired Immunodeficiency Syndrome: Implications for Comprehensive Patient Care.
- P. A. VOLBERDING (1985)
Ann Intern Med
103, 729-733
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- The Acquired Immunodeficiency Syndrome in Infants and Children.
- A. J. AMMANN (1985)
Ann Intern Med
103, 734-737
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- Thrombocytopenia in Homosexual Patients: Prognosis, Response to Therapy, and Prevalence of Antibody to the Retrovirus Associated with the Acquired Immunodeficiency Syndrome.
- C. WALSH, R. KRIGEL, E. LENNETTE, and S. KARPATKIN (1985)
Ann Intern Med
103, 542-545
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- Transient Antibody to Lymphadenopathy-Associated Virus/Human T-Lymphotropic Virus Type III and T-Lymphocyte Abnormalities in the Wife of a Man Who Developed the Acquired Immunodeficiency Syndrome.
- H. BURGER, B. WEISER, W. S. ROBINSON, J. LIFSON, E. ENGLEMAN, C. ROUZIOUX, F. BRUN-VEZINET, F. BARRE-SINOUSSI, L. MONTAGNIER, and J.-C. CHERMANN (1985)
Ann Intern Med
103, 545-547
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- The epidemiology of AIDS: current status and future prospects.
- J. Curran, W. Morgan, A. Hardy, H. Jaffe, W. Darrow, and W. Dowdle (1985)
Science
229, 1352-1357
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- Transcription of novel open reading frames of AIDS retrovirus during infection of lymphocytes.
- A. Rabson, D. Daugherty, S Venkatesan, K. Boulukos, S. Benn, T. Folks, P Feorino, and M. Martin (1985)
Science
229, 1388-1390
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