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Science 24 August 1984:
Vol. 225. no. 4664, pp. 808 - 811
DOI: 10.1126/science.6382604
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Articles

Science, Vol 225, Issue 4664, 808-811
Copyright © 1984 by American Association for the Advancement of Science

articles

Evolutionary relatedness of Plasmodium species as determined by the structure of DNA

TF McCutchan, JB Dame, LH Miller, and J Barnwell

Malaria parasites can be grouped evolutionarily by analysis of DNA composition and genome arrangement. Those that vary widely with regard to host range, morphology, and biological characteristics fit into only a small number of distinctive groups. The DNA of the human parasite Plasmodium falciparum fits into a group that includes rodent and avian malarias and is unlike the DNA of other primate malaria parasites. The DNA of Plasmodium vivax, which is also a human parasite, fits into a distinctly different group that includes Plasmodium cynomolgi, a parasite of monkeys. The evolutionary lines suggested here appear to be consistent with similarities seen among malaria parasites with regard to gene sequence.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Origins of Human Malaria: Rare Genomic Changes and Full Mitochondrial Genomes Confirm the Relationship of Plasmodium falciparum to Other Mammalian Parasites but Complicate the Origins of Plasmodium vivax.
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Plasmodium falciparum Possesses a Cell Cycle-regulated Short Type Replication Protein A Large Subunit Encoded by an Unusual Transcript.
T. S. Voss, T. Mini, P. Jenoe, and H.-P. Beck (2002)
J. Biol. Chem. 277, 17493-17501
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Coevolutionary Genetics of Plasmodium Malaria Parasites and Their Human Hosts.
A. G. Evans and T. E. Wellems (2002)
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Monoclonal Antibody against the Plasmodium falciparum Chitinase, PfCHT1, Recognizes a Malaria Transmission-Blocking Epitope in Plasmodium gallinaceum Ookinetes Unrelated to the Chitinase PgCHT1.
R. C. Langer, F. Li, V. Popov, A. Kurosky, and J. M. Vinetz (2002)
Infect. Immun. 70, 1581-1590
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Identification of Novel Plasmodium gallinaceum Zygote- and Ookinete-Expressed Proteins as Targets for Blocking Malaria Transmission.
R. C. Langer, F. Li, and J. M. Vinetz (2002)
Infect. Immun. 70, 102-106
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Interspecies conservation of gene order and intron-exon structure in a genomic locus of high gene density and complexity in Plasmodium.
L. H. M. van Lin, T. Pace, C. J. Janse, C. Birago, J. Ramesar, L. Picci, M. Ponzi, and A. P. Waters (2001)
Nucleic Acids Res. 29, 2059-2068
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Genetic Polymorphism and Natural Selection in the Malaria Parasite Plasmodium falciparum.
A. A. Escalante, A. A. Lal, and F. J. Ayala (1998)
Genetics 149, 189-202
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Baculovirus Merozoite Surface Protein 1 C-Terminal Recombinant Antigens Are Highly Protective in a Natural Primate Model for Human Plasmodium vivax Malaria.
K. L. R. L. Perera, S. M. Handunnetti, I. Holm, S. Longacre, and K. Mendis (1998)
Infect. Immun. 66, 1500-1506
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Transfection of the Primate Malaria Parasite Plasmodium knowlesi Using Entirely Heterologous Constructs.
A. M. v. d. Wel, A. M. Tomas, C. H.M. Kocken, P. Malhotra, C. J. Janse, A. P. Waters, and A. W. Thomas (1997)
J. Exp. Med. 185, 1499-1504
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Circumsporozoite protein heterogeneity in the human malaria parasite Plasmodium vivax.
R Rosenberg, R. Wirtz, D. Lanar, J Sattabongkot, T Hall, A. Waters, and C Prasittisuk (1989)
Science 245, 973-976
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Sequence of the immunodominant epitope for the surface protein on sporozoites of Plasmodium vivax.
T. McCutchan, A. Lal, V. de la Cruz, L. Miller, W. Maloy, Y Charoenvit, R. Beaudoin, P Guerry, R Wistar Jr, S. Hoffman, et al. (1985)
Science 230, 1381-1383
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Circumsporozoite protein of Plasmodium vivax: gene cloning and characterization of the immunodominant epitope.
D. Arnot, J. Barnwell, J. Tam, V Nussenzweig, R. Nussenzweig, and V Enea (1985)
Science 230, 815-818
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