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Science 17 August 1984:
Vol. 225. no. 4663, pp. 743 - 745
DOI: 10.1126/science.6087456
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Articles

Science, Vol 225, Issue 4663, 743-745
Copyright © 1984 by American Association for the Advancement of Science

articles

Leukotriene B4 produces hyperalgesia that is dependent on polymorphonuclear leukocytes

JD Levine, W Lau, G Kwiat, and EJ Goetzl

Leukotriene B4, at the same intracutaneous doses as bradykinin, reduced the nociceptive threshold in the rat paw. The mechanism of leukotriene B4-induced hyperalgesia was distinguished from that of the hyperalgesia elicited by prostaglandin E2 and bradykinin by its dependence on polymorphonuclear leukocytes and independence of the cyclooxygenation of arachidonic acid.


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