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Science 17 August 1984:
Vol. 225. no. 4663, pp. 723 - 725
DOI: 10.1126/science.6087455
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Articles

Science, Vol 225, Issue 4663, 723-725
Copyright © 1984 by American Association for the Advancement of Science

articles

Immunologically induced alterations of airway smooth muscle cell membrane

M Souhrada and JF Souhrada

Active and passive sensitization, both in vivo and in vitro, caused significant hyperpolarization of airway smooth muscle cell preparations isolated from guinea pigs. An increase in the contribution of the electrogenic Na+ pump to the resting membrane potential was responsible for this change. Hyperpolarization, as induced by passive sensitization, was not prevented by agents that inhibit specific mediators of anaphylaxis but was abolished when serum from sensitized animals was heated. The heat-sensitive serum factor, presumably reaginic antibodies, appears to be responsible for the membrane hyperpolarization of airway smooth muscle cells after sensitization.


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