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Science 17 August 1984:
Vol. 225. no. 4663, pp. 721 - 723
DOI: 10.1126/science.6087454
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Articles

Science, Vol 225, Issue 4663, 721-723
Copyright © 1984 by American Association for the Advancement of Science

articles

A cell line expressing vesicular stomatitis virus glycoprotein fuses at low pH

RZ Florkiewicz and JK Rose

A stable cell line expressing a complementary DNA clone encoding the vesicular stomatitis virus glycoprotein fused and formed polykaryons at pH 5.5. The formation of polykaryons was dependent on the presence of glycoprotein anchored at the cell surface and could be prevented by incubation of cells with a monoclonal antibody to the glycoprotein. Fusion occurred at a pH 0.5 unit lower than that observed for cells infected with vesicular stomatitis virus.


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