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Science 10 August 1984:
Vol. 225. no. 4662, pp. 639 - 641
DOI: 10.1126/science.6740331
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Articles

Science, Vol 225, Issue 4662, 639-641
Copyright © 1984 by American Association for the Advancement of Science

articles

Independent developmental programs for two estrogen-regulated genes

A Elbrecht, CB Lazier, AA Protter, and DL Williams

Measurement of hepatic apolipoprotein II and vitellogenin II messenger RNA during chicken embryogenesis showed that these genes acquire estrogen responsiveness at different stages of development. Sensitive solution hybridization assays with excess complementary DNA showed that apolipoprotein II transcripts were induced to 500 molecules per cell at day 9, whereas induction of vitellogenin II messenger RNA was not found until day 11. Thus, two estrogen regulated genes of common function and coordinately regulated in the adult may be on independent developmental programs.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Arsenic as an Endocrine Disruptor: Effects of Arsenic on Estrogen Receptor-Mediated Gene Expression In Vivo and in Cell Culture.
J. C. Davey, J. E. Bodwell, J. A. Gosse, and J. W. Hamilton (2007)
Toxicol. Sci. 98, 75-86
   Abstract »    Full Text »    PDF »
Isolation of chicken vitellogenin I and III cDNAs and the developmental regulation of five estrogen-responsive genes in the embryonic liver..
M I Evans, R Silva, and J B Burch (1988)
Genes & Dev. 2, 116-124
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)