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Science 10 August 1984:
Vol. 225. no. 4662, pp. 636 - 639
DOI: 10.1126/science.6740330
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Articles

Science, Vol 225, Issue 4662, 636-639
Copyright © 1984 by American Association for the Advancement of Science

articles

Transforming potential of human c-sis nucleotide sequences encoding platelet-derived growth factor

SF Josephs, L Ratner, MF Clarke, EH Westin, MS Reitz, and F Wong-Staal

The nucleotide sequence of a transforming human c-sis complementary DNA shows an open reading frame 723 base pairs in length located downstream from an in-phase terminator thymine-guanine-adenine codon. Sequences within this region were identical to those previously determined for the exons of the normal human c-sis gene. Thus, the predicted transforming product, a protein of 27,281 daltons, may be the actual precursor for normal human platelet-derived growth factor chain A.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
High-affinity Binding of Basic Fibroblast Growth Factor and Platelet-derived Growth Factor-AA to the Core Protein of the NG2 Proteoglycan.
L. Goretzki, M. A. Burg, K. A. Grako, and W. B. Stallcup (1999)
J. Biol. Chem. 274, 16831-16837
   Abstract »    Full Text »    PDF »
The Tax Protein of Human T-cell Leukemia Virus Type 1 Mediates the Transactivation of the c-sis/Platelet-derived Growth Factor-B Promoter through Interactions with the Zinc Finger Transcription Factors Sp1 and NGFI-A/Egr-1.
S. R. Trejo, W. E. Fahl, and L. Ratner (1997)
J. Biol. Chem. 272, 27411-27421
   Abstract »    Full Text »    PDF »
Growth Factors and the Arterial Wall: Implications for Vessel Repair, Atherosclerosis, and Intimal Hyperplasia.
D. A. Bull, G. C. Hunter, and C. W Putnam (1991)
Perspectives in Vascular Surgery and Endovascular Therapy 4, 87-103
   PDF »


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