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Science 10 August 1984:
Vol. 225. no. 4662, pp. 634 - 636
DOI: 10.1126/science.6330900
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Articles

Science, Vol 225, Issue 4662, 634-636
Copyright © 1984 by American Association for the Advancement of Science

articles

Cellular transformation by human papillomavirus DNA in vitro

SL Watts, WC Phelps, RS Ostrow, KR Zachow, and AJ Faras

Molecularly cloned DNA's of human papillomaviruses HPV-5 and HPV-l induced morphological transformation of mouse C127 cells in culture. Single-cell clones of cells transformed by papillomavirus contained multiple persistent episomal copies of the transfected DNA species and were analyzed for growth characteristics indicating malignant potential.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)