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Science 10 August 1984:
Vol. 225. no. 4662, pp. 628 - 630
DOI: 10.1126/science.6204384
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Articles
Science, Vol 225, Issue 4662, 628-630
Copyright © 1984 by American Association for the Advancement of Science
DNA cloning of Plasmodium falciparum circumsporozoite gene: amino acid sequence of repetitive epitope
V Enea,
J Ellis,
F Zavala,
DE Arnot,
A Asavanich,
A Masuda,
I Quakyi,
and
RS Nussenzweig
A clone of complementary DNA encoding the circumsporozoite (CS) protein of the human malaria parasite Plasmodium falciparum has been isolated by screening an Escherichia coli complementary DNA library with a monoclonal antibody to the CS protein. The DNA sequence of the complementary DNA insert encodes a four-amino acid sequence: proline-asparagine-alanine-asparagine, tandemly repeated 23 times. The CS beta-lactamase fusion protein specifically binds monoclonal antibodies to the CS protein and inhibits the binding of these antibodies to native Plasmodium falciparum CS protein. These findings provide a basis for the development of a vaccine against Plasmodium falciparum malaria.
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