Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 3 August 1984:
Vol. 225. no. 4661, pp. 523 - 525
DOI: 10.1126/science.6330898
Prev | Table of Contents | Next

Articles

Science, Vol 225, Issue 4661, 523-525
Copyright © 1984 by American Association for the Advancement of Science

articles

Voltage-dependent sodium channels in an invertebrate striated muscle

LM Schwartz and W Stuhmer

Striated skeletal muscles from the planktonic arrowworm Sagitta elegans (phylum Chaetognatha) were voltage-clamped. The muscles displayed classical voltage-dependent sodium channels that (i) showed peak transient currents when the membrane was depolarized 90 millivolts from rest, (ii) opened rapidly with peak currents flowing within 0.4 milliseconds at 4 degrees C, (iii) showed voltage-dependent inactivation with 50 percent inactivation at +25 millivolts from rest, and (iv) were blocked by 500 nanomolar tetrodotoxin.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A Novel Leg-Shaking Drosophila Mutant Defective in a Voltage-Gated K+ Current and Hypersensitive to Reactive Oxygen Species.
J. W. Wang, J. M. Humphreys, J. P. Phillips, A. J. Hilliker, and C.-F. Wu (2000)
J. Neurosci. 20, 5958-5964
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)