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Science 27 July 1984:
Vol. 225. no. 4660, pp. 432 - 434
DOI: 10.1126/science.6330896
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Articles

Science, Vol 225, Issue 4660, 432-434
Copyright © 1984 by American Association for the Advancement of Science

articles

Single channel studies on inactivation of calcium currents

HD Lux and AM Brown

Inactivation of calcium channels has been attributed to a direct reaction of calcium ions entering the cell with the calcium channel. For a single channel this hypothesis predicts a correlation between the amount of calcium entering during an opening or a burst of openings and the subsequent closed times. No such correlation was found, and the possibility that, upon entry, calcium ions produce inactivation is excluded.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Voltage and Calcium Use the Same Molecular Determinants to Inactivate Calcium Channels.
T. Cens, S. Restituito, S. Galas, and P. Charnet (1999)
J. Biol. Chem. 274, 5483-5490
   Abstract »    Full Text »    PDF »
Calcium-sensitive inactivation in the gating of single calcium channels.
D. Yue, P. Backx, and J. Imredy (1990)
Science 250, 1735-1738
   Abstract »    PDF »
The Calcium Deficiency Hypothesis of Hypertension: A Critique.
N. M. KAPLAN and R. B. MEESE (1986)
Ann Intern Med 105, 947-955
   Abstract »    PDF »


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