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Science 27 July 1984:
Vol. 225. no. 4660, pp. 421 - 424
DOI: 10.1126/science.6204380
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Articles

Science, Vol 225, Issue 4660, 421-424
Copyright © 1984 by American Association for the Advancement of Science

articles

Sequence of the envelope glycoprotein gene of type II human T lymphotropic virus

J Sodroski, R Patarca, D Perkins, D Briggs, TH Lee, M Essex, J Coligan, F Wong-Staal, RC Gallo, and WA Haseltine

The sequence of the envelope glycoprotein gene of type II human T lymphotropic virus (HTLV) is presented. The predicted amino acid sequence is similar to that of the corresponding protein of HTLV type I, in that the proteins share the same amino acids at 336 of 488 residues, and 68 of the 152 differences are of a conservative nature. The overall structural similarity of these proteins provides an explanation for the antigenic cross-reactivity observed among diverse members of the HTLV retrovirus family by procedures that assay for the viral envelope glycoprotein, for example, membrane immunofluorescence.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Early Assembly Step of a Retroviral Envelope Glycoprotein: Analysis Using a Dominant Negative Assay.
A. R. Rosenberg, L. Delamarre, C. Pique, I. Le Blanc, G. Griffith, and M.-C. Dokhelar (1999)
J. Cell Biol. 145, 57-68
   Abstract »    Full Text »    PDF »
Determinants of Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Activation by Soluble CD4 and Monoclonal Antibodies.
N. Sullivan, Y. Sun, J. Binley, J. Lee, C. F. Barbas III, P. W. H. I. Parren, D. R. Burton, and J. Sodroski (1998)
J. Virol. 72, 6332-6338
   Abstract »    Full Text »    PDF »
Functional relation between HTLV-II x and adenovirus E1A proteins in transcriptional activation.
I. Chen, A. Cann, N. Shah, and R. Gaynor (1985)
Science 230, 570-573
   Abstract »    PDF »
The x gene is essential for HTLV replication.
I. Chen, D. Slamon, J. Rosenblatt, N. Shah, S. Quan, and W Wachsman (1985)
Science 229, 54-58
   Abstract »    PDF »
Major glycoprotein antigens that induce antibodies in AIDS patients are encoded by HTLV-III.
J. Allan, J. Coligan, F Barin, M. McLane, J. Sodroski, C. Rosen, W. Haseltine, T. Lee, and M Essex (1985)
Science 228, 1091-1094
   Abstract »    PDF »
Nucleotide sequence and expression of an AIDS-associated retrovirus (ARV-2).
R Sanchez-Pescador, M. Power, P. Barr, K. Steimer, M. Stempien, S. Brown-Shimer, W. Gee, A Renard, A Randolph, J. Levy, et al. (1985)
Science 227, 484-492
   Abstract »    PDF »
Molecular characterization of human T-cell leukemia (lymphotropic) virus type III in the acquired immune deficiency syndrome.
G. Shaw, B. Hahn, S. Arya, J. Groopman, R. Gallo, and F Wong-Staal (1984)
Science 226, 1165-1171
   Abstract »    PDF »
Structure of 3' terminal region of type II human T lymphotropic virus: evidence for new coding region.
W. Haseltine, J Sodroski, R Patarca, D Briggs, D Perkins, and F Wong-Staal (1984)
Science 225, 419-421
   Abstract »    PDF »


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