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Science 27 July 1984:
Vol. 225. no. 4660, pp. 419 - 421
DOI: 10.1126/science.6330894
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Articles

Science, Vol 225, Issue 4660, 419-421
Copyright © 1984 by American Association for the Advancement of Science

articles

Structure of 3' terminal region of type II human T lymphotropic virus: evidence for new coding region

WA Haseltine, J Sodroski, R Patarca, D Briggs, D Perkins, and F Wong-Staal

The sequence of the 3' terminus of the human T lymphotropic virus type II (HTLV-II) was determined and compared to the corresponding sequence of HTLV-I. The 1557-nucleotide-long sequence can be divided into a 5' region that is not conserved between the two viruses, and a 3', 1011-nucleotide-long region that is highly conserved and that corresponds precisely with a long open reading frame for both HTLV-I and -II. The proteins that could be encoded by these open reading frames have a molecular weight of about 38,000 and are closely related in primary amino acid sequence. The genomic structure in the 3' region of HTLV was found to be similar to that of bovine leukemia virus.


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Functional relation between HTLV-II x and adenovirus E1A proteins in transcriptional activation.
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The pX protein of HTLV-I is a transcriptional activator of its long terminal repeats.
B. Felber, H Paskalis, C Kleinman-Ewing, F Wong-Staal, and G. Pavlakis (1985)
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The x gene is essential for HTLV replication.
I. Chen, D. Slamon, J. Rosenblatt, N. Shah, S. Quan, and W Wachsman (1985)
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Location of the trans-activating region on the genome of human T-cell lymphotropic virus type III.
J Sodroski, R Patarca, C Rosen, F Wong-Staal, and W Haseltine (1985)
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Expression of the pX gene of HTLV-I: general splicing mechanism in the HTLV family.
M Seiki, A Hikikoshi, T Taniguchi, and M Yoshida (1985)
Science 228, 1532-1534
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HTLV x-gene product: requirement for the env methionine initiation codon.
W Wachsman, D. Golde, P. Temple, E. Orr, S. Clark, and I. Chen (1985)
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A transcriptional activator protein encoded by the x-lor region of the human T-cell leukemia virus.
J Sodroski, C Rosen, W. Goh, and W Haseltine (1985)
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Expression in Escherichia coli of open reading frame gene segments of HTLV-III.
N. Chang, P. Chanda, A. Barone, S McKinney, D. Rhodes, S. Tam, C. Shearman, J Huang, T. Chang, R. Gallo, et al. (1985)
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Subcellular localization of the product of the long open reading frame of human T-cell leukemia virus type I.
W. Goh, J Sodroski, C Rosen, M Essex, and W. Haseltine (1985)
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Nucleotide sequence and expression of an AIDS-associated retrovirus (ARV-2).
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Trans activation of the bovine leukemia virus long terminal repeat in BLV-infected cells.
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Trans-acting transcriptional regulation of human T-cell leukemia virus type III long terminal repeat.
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Molecular characterization of human T-cell leukemia (lymphotropic) virus type III in the acquired immune deficiency syndrome.
G. Shaw, B. Hahn, S. Arya, J. Groopman, R. Gallo, and F Wong-Staal (1984)
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Diagnostic potential for human malignancies of bacterially produced HTLV-I envelope protein.
K. Samuel, J. Lautenberger, C. Jorcyk, S Josephs, F Wong-Staal, and T. Papas (1984)
Science 226, 1094-1097
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Expression of the 3' terminal region of human T-cell leukemia viruses.
W Wachsman, K Shimotohno, S. Clark, D. Golde, and I. Chen (1984)
Science 226, 177-179
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Antigens encoded by the 3'-terminal region of human T-cell leukemia virus: evidence for a functional gene.
T. Lee, J. Coligan, J. Sodroski, W. Haseltine, S. Salahuddin, F Wong-Staal, R. Gallo, and M Essex (1984)
Science 226, 57-61
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Identification of the putative transforming protein of the human T-cell leukemia viruses HTLV-I and HTLV-II.
D. Slamon, K Shimotohno, M. Cline, D. Golde, and I. Chen (1984)
Science 226, 61-65
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Trans-acting transcriptional activation of the long terminal repeat of human T lymphotropic viruses in infected cells.
J. Sodroski, C. Rosen, and W. Haseltine (1984)
Science 225, 381-385
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How the HTLV's might cause cancer.
J. Marx (1984)
Science 225, 398-399
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