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Science 27 July 1984:
Vol. 225. no. 4660, pp. 381 - 385
DOI: 10.1126/science.6330891
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Articles

Science, Vol 225, Issue 4660, 381-385
Copyright © 1984 by American Association for the Advancement of Science

articles

Trans-acting transcriptional activation of the long terminal repeat of human T lymphotropic viruses in infected cells

JG Sodroski, CA Rosen, and WA Haseltine

The transcription initiation signals for retroviruses lie within the long terminal repeat (LTR) sequences that flank the integrated provirus. Two subtypes of human T lymphotropic virus (HTLV) are associated with different disease phenotypes. In this article it is shown that marked differences exist in the ability of LTR sequences of these subtypes to function as transcriptional elements in differentiated cell types. It is also shown that trans-acting regulatory factors present in HTLV-infected cells stimulate gene expression directed by these LTR sequences in a type-specific manner. These results have implications for understanding the diverse biological effects of HTLV infection.


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The Multichain Interleukin-2 Receptor: A Target for Immunotherapy.
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Ann Intern Med 116, 148-160
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Identification of HTLV-I tax trans-activator mutants exhibiting novel transcriptional phenotypes..
M R Smith and W C Greene (1990)
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HTLV-I trans-activator protein, tax, is a trans-repressor of the human beta-polymerase gene.
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T. A. Waldmann (1990)
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Comparative analysis of the HTLV-I Rex and HIV-1 Rev trans-regulatory proteins and their RNA response elements..
S M Hanly, L T Rimsky, M H Malim, J H Kim, J Hauber, M Duc Dodon, S Y Le, J V Maizel, B R Cullen, and W C Greene (1989)
Genes & Dev. 3, 1534-1544
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HTLV-I tax induces cellular proteins that activate the kappa B element in the IL-2 receptor alpha gene.
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Ann Intern Med 109, 274-279
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Cellular transcription factors and regulation of IL-2 receptor gene expression by HTLV-I tax gene product.
S Ruben, H Poteat, T. Tan, K Kawakami, R Roeder, W Haseltine, and C. Rosen (1988)
Science 241, 89-92
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Retroviruses.
H Varmus (1988)
Science 240, 1427-1435
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HTLV-II transactivation is regulated by the overlapping tax/rex nonstructural genes.
J. Rosenblatt, A. Cann, D. Slamon, I. Smalberg, N. Shah, J Fujii, W Wachsman, and I. Chen (1988)
Science 240, 916-919
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The tat gene of human T-lymphotropic virus type 1 induces mesenchymal tumors in transgenic mice.
M Nerenberg, S. Hinrichs, R. Reynolds, G Khoury, and G Jay (1987)
Science 237, 1324-1329
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Developmental Therapeutics and the Acquired Immunodeficiency Syndrome.
V. T. DEVITA Jr., S. BRODER, A. S. FAUCI, J. A. KOVACS, and B. A. CHABNER (1987)
Ann Intern Med 106, 568-581
   Abstract »    PDF »
U3 sequences from HTLV-I and -II LTRs confer pX protein response to a murine leukemia virus LTR.
H Kitado, I. Chen, N. Shah, A. Cann, K Shimotohno, and H Fan (1987)
Science 235, 901-904
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The Human Interleukin-2 Receptor: Normal and Abnormal Expression in T Cells and in Leukemias Induced by the Human T-Lymphotropic Retroviruses.
W. C. GREENE, W. J. LEONARD, J. M. DEPPER, D. L. NELSON, and T. A. WALDMANN (1986)
Ann Intern Med 105, 560-572
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Trans-activator gene of HTLV-II induces IL-2 receptor and IL-2 cellular gene expression.
W. Greene, W. Leonard, Y Wano, P. Svetlik, N. Peffer, J. Sodroski, C. Rosen, W. Goh, and W. Haseltine (1986)
Science 232, 877-880
   Abstract »    PDF »
The structure, function, and expression of interleukin-2 receptors on normal and malignant lymphocytes.
T. Waldmann (1986)
Science 232, 727-732
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Chronic Leukemias: Oncogenes, Chromosomes, and Advances in Therapy.
R. CHAMPLIN, R. P. GALE, K. A. FOON, and D. W. GOLDE (1986)
Ann Intern Med 104, 671-688
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In vivo competition between a metallothionein regulatory element and the SV40 enhancer.
H Scholer, A Haslinger, A Heguy, H Holtgreve, and M Karin (1986)
Science 232, 76-80
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Two elements in the bovine leukemia virus long terminal repeat that regulate gene expression.
D Derse and J. Casey (1986)
Science 231, 1437-1440
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Long-term cultures of HTLV-III--infected T cells: a model of cytopathology of T-cell depletion in AIDS.
D Zagury, J Bernard, R Leonard, R Cheynier, M Feldman, P. Sarin, and R. Gallo (1986)
Science 231, 850-853
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The Human Interleukin-2 Receptor: Role in Normal T-cell Growth and Association with HTLV-I-induced T-cell Leukemia.
W.C. Greene, J.M. Depper, M. Kronke, and W.J. Leonard (1986)
Cold Spring Harb Symp Quant Biol 51, 731-737
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The action of oncogenes in the cytoplasm and nucleus.
R. Weinberg (1985)
Science 230, 770-776
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A new HTLV-III/LAV encoded antigen detected by antibodies from AIDS patients.
J. Allan, J. Coligan, T. Lee, M. McLane, P. Kanki, J. Groopman, and M Essex (1985)
Science 230, 810-813
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The pX protein of HTLV-I is a transcriptional activator of its long terminal repeats.
B. Felber, H Paskalis, C Kleinman-Ewing, F Wong-Staal, and G. Pavlakis (1985)
Science 229, 675-679
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Infection of HTLV-III/LAV in HTLV-I-carrying cells MT-2 and MT-4 and application in a plaque assay.
S Harada, Y Koyanagi, and N Yamamoto (1985)
Science 229, 563-566
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cis- and trans-acting transcriptional regulation of visna virus.
J. Hess, J. Clements, and O Narayan (1985)
Science 229, 482-485
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Trans-activator gene of human T-lymphotropic virus type III (HTLV-III).
S. Arya, C Guo, S. Josephs, and F Wong-Staal (1985)
Science 229, 69-73
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Location of the trans-activating region on the genome of human T-cell lymphotropic virus type III.
J Sodroski, R Patarca, C Rosen, F Wong-Staal, and W Haseltine (1985)
Science 229, 74-77
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Chronic Lymphocytic Leukemia: Recent Advances in Biology and Treatment.
R. P. GALE and K. A. FOON (1985)
Ann Intern Med 103, 101-120
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Expression of the pX gene of HTLV-I: general splicing mechanism in the HTLV family.
M Seiki, A Hikikoshi, T Taniguchi, and M Yoshida (1985)
Science 228, 1532-1534
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HTLV x-gene product: requirement for the env methionine initiation codon.
W Wachsman, D. Golde, P. Temple, E. Orr, S. Clark, and I. Chen (1985)
Science 228, 1534-1537
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Studies of the putative transforming protein of the type I human T-cell leukemia virus.
D. Slamon, M. Press, L. Souza, D. Murdock, M. Cline, D. Golde, J. Gasson, and I. Chen (1985)
Science 228, 1427-1430
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A transcriptional activator protein encoded by the x-lor region of the human T-cell leukemia virus.
J Sodroski, C Rosen, W. Goh, and W Haseltine (1985)
Science 228, 1430-1434
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Deregulation of interleukin-2 receptor gene expression in HTLV-I-induced adult T-cell leukemia.
M Kronke, W. Leonard, J. Depper, and W. Greene (1985)
Science 228, 1215-1217
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Major glycoprotein antigens that induce antibodies in AIDS patients are encoded by HTLV-III.
J. Allan, J. Coligan, F Barin, M. McLane, J. Sodroski, C. Rosen, W. Haseltine, T. Lee, and M Essex (1985)
Science 228, 1091-1094
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Expression in Escherichia coli of open reading frame gene segments of HTLV-III.
N. Chang, P. Chanda, A. Barone, S McKinney, D. Rhodes, S. Tam, C. Shearman, J Huang, T. Chang, R. Gallo, et al. (1985)
Science 228, 93-96
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Subcellular localization of the product of the long open reading frame of human T-cell leukemia virus type I.
W. Goh, J Sodroski, C Rosen, M Essex, and W. Haseltine (1985)
Science 227, 1227-1228
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Bovine leukemia virus long terminal repeat: a cell type-specific promoter.
D Derse, S. Caradonna, and J. Casey (1985)
Science 227, 317-320
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Trans-acting transcriptional regulation of human T-cell leukemia virus type III long terminal repeat.
J Sodroski, C Rosen, F Wong-Staal, S. Salahuddin, M Popovic, S Arya, R. Gallo, and W. Haseltine (1985)
Science 227, 171-173
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Sequence homology and morphologic similarity of HTLV-III and visna virus, a pathogenic lentivirus.
M. Gonda, F Wong-Staal, R. Gallo, J. Clements, O Narayan, and R. Gilden (1985)
Science 227, 173-177
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Molecular characterization of human T-cell leukemia (lymphotropic) virus type III in the acquired immune deficiency syndrome.
G. Shaw, B. Hahn, S. Arya, J. Groopman, R. Gallo, and F Wong-Staal (1984)
Science 226, 1165-1171
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Expression of the 3' terminal region of human T-cell leukemia viruses.
W Wachsman, K Shimotohno, S. Clark, D. Golde, and I. Chen (1984)
Science 226, 177-179
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Antigens encoded by the 3'-terminal region of human T-cell leukemia virus: evidence for a functional gene.
T. Lee, J. Coligan, J. Sodroski, W. Haseltine, S. Salahuddin, F Wong-Staal, R. Gallo, and M Essex (1984)
Science 226, 57-61
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Identification of the putative transforming protein of the human T-cell leukemia viruses HTLV-I and HTLV-II.
D. Slamon, K Shimotohno, M. Cline, D. Golde, and I. Chen (1984)
Science 226, 61-65
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How the HTLV's might cause cancer.
J. Marx (1984)
Science 225, 398-399
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