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Science 20 July 1984:
Vol. 225. no. 4659, pp. 342 - 344
DOI: 10.1126/science.6539947
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Articles

Science, Vol 225, Issue 4659, 342-344
Copyright © 1984 by American Association for the Advancement of Science

articles

Monoclonal antibody to a human germ cell membrane glycoprotein that inhibits fertilization

RK Naz, NJ Alexander, M Isahakia, and MS Hamilton

A monoclonal antibody to an antigen in the human germ cell membrane did not agglutinate or immobilize sperm but inhibited binding and penetration of zona-free hamster ova by human sperm and blocked murine fertilization in vitro. The antibody, of the 2a subclass of immunoglobulin G, was germ cell-specific but not species-specific. It recognized a single antigen of 23 kilodaltons that has been isolated from human germ cells. This fertilization antigen, located on the postacrosome , midpiece, and tail of human sperm, is a glycoprotein of testicular origin associated with some types of human involuntary immunoinfertility .


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Human Sperm-Specific Peptide Vaccine That Causes Long-Term Reversible Contraception.
R. K. Naz and S. C. Chauhan (2002)
Biol Reprod 67, 674-680
   Abstract »    Full Text »    PDF »
FSP95, A Testis-Specific 95-Kilodalton Fibrous Sheath Antigen That Undergoes Tyrosine Phosphorylation in Capacitated Human Spermatozoa.
A. Mandal, S. Naaby-Hansen, M. J. Wolkowicz, K. Klotz, J. Shetty, J. D. Retief, S. A. Coonrod, M. Kinter, N. Sherman, F. Cesar, et al. (1999)
Biol Reprod 61, 1184-1197
   Abstract »    Full Text »
Involvement of Protein Serine and Threonine Phosphorylation in Human Sperm Capacitation.
R. K. Naz (1999)
Biol Reprod 60, 1402-1409
   Abstract »    Full Text »
Recombinant Fertilization Antigen-1 Causes a Contraceptive Effect in Actively Immunized Mice.
R. K. Naz and X. Zhu (1998)
Biol Reprod 59, 1095-1100
   Abstract »    Full Text »
Fertilization antigen-1: cDNA cloning, testis-specific expression, and immunocontraceptive effects.
X. Zhu and R. K. Naz (1997)
PNAS 94, 4704-4709
   Abstract »    Full Text »    PDF »


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