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Science 20 July 1984:
Vol. 225. no. 4659, pp. 326 - 328
DOI: 10.1126/science.6204379
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Articles

Science, Vol 225, Issue 4659, 326-328
Copyright © 1984 by American Association for the Advancement of Science

articles

Growth hormone-releasing factor stimulates pancreatic enzyme secretion

SJ Pandol, H Seifert, MW Thomas, J Rivier, and W Vale

Growth hormone-releasing factors (GRF's) from two human pancreatic tumors (hpGRF's) that caused acromegaly and from the rat hypothalamus ( rhGRF ) were recently isolated and characterized. Although these peptides are potent growth hormone secretagogues, they have not until now been described to have actions outside the pituitary. These GRF's were shown to stimulate digestive enzyme secretion from an exocrine pancreatic preparation in vitro, rhGRF being more than 100 times as potent as hpGRF. Adenosine 3',5'-monophosphate mediates this action of the GRF's.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Expression of Growth Hormone-Releasing Hormone (GHRH) Messenger Ribonucleic Acid and the Presence of Biologically Active GHRH in Human Breast, Endometrial, and Ovarian Cancers.
Z. Kahán, J. M. Arencibia, V. J. Csernus, K. Groot, R. D. Kineman, W. R. Robinson, and A. V. Schally (1999)
J. Clin. Endocrinol. Metab. 84, 582-589
   Abstract »    Full Text »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)