Related Content
Search Google Scholar for:
|
|
Science 20 July 1984:
Vol. 225. no. 4659, pp. 321 - 323
DOI: 10.1126/science.6330889
|
|
Articles
Science, Vol 225, Issue 4659, 321-323
Copyright © 1984 by American Association for the Advancement of Science
Antibodies to the core protein of lymphadenopathy-associated virus (LAV) in patients with AIDS
VS Kalyanaraman,
CD Cabradilla,
JP Getchell,
R Narayanan,
EH Braff,
JC Chermann,
F Barre-Sinoussi,
L Montagnier,
TJ Spira,
J Kaplan,
and
al. et
Lymphadenopathy-associated virus ( LAV ), a human T- lymphotrophic retrovirus isolated from a homosexual man with lymphadenopathy, has been causally associated with acquired immunodeficiency syndrome (AIDS). A sensitive and specific radioimmunoprecipitation test was developed for the detection of antibodies to the major core protein of LAV , p25 (molecular weight 25,000). Antibody to LAV p25 was found in the serum of 51 of 125 AIDS patients, 81 of 113 patients with lymphadenopathy syndrome, 0 of 70 workers at the Centers for Disease Control (some of whom had handled specimens from AIDS patients), and 0 of 189 random blood donors. Of a group of 100 homosexual men from San Francisco whose serum was obtained in 1978, only one had antibody to LAV p25; in contrast, of a group of 50 homosexual men in the same community whose serum was obtained in 1984, 12 had antibodies to LAV p25.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- Prevalence of Antibodies to HTLV-I, -II, and -III in Intravenous Drug Abusers From an AIDS Endemic Region.
- M. Robert-Guroff, S. H. Weiss, J. A. Giron, A. M. Jennings, H. M. Ginzburg, I. B. Margolis, W. A. Blattner, and R. C. Gallo (1986)
JAMA
255, 3133-3137
| Abstract »
| PDF »
- Unexplained Lymphadenopathy in Homosexual Men: A Longitudinal Study.
- D. B. Fishbein, J. E. Kaplan, T. J. Spira, B. Miller, L. B. Schonberger, P. F. Pinsky, J. P. Getchell, V. S. Kalyanaraman, and J. S. Braude (1985)
JAMA
254, 930-935
| Abstract »
| PDF »
- Infection With HTLV-III/LAV and Transfusion-Associated Acquired Immunodeficiency Syndrome: Serologic Evidence of an Association.
- H. W. Jaffe, M. G. Sarngadharan, A. L. DeVico, L. Bruch, J. P. Getchell, V. S. Kalyanaraman, H. W. Haverkos, R. L. Stoneburner, R. C. Gallo, and J. W. Curran (1985)
JAMA
254, 770-773
| Abstract »
| PDF »
- Infection of HTLV-III/LAV in HTLV-I-carrying cells MT-2 and MT-4 and application in a plaque assay.
- S Harada, Y Koyanagi, and N Yamamoto (1985)
Science
229, 563-566
| Abstract »
| PDF »
- Antibody to Human T-Lymphotropic Virus Type III in Wives of Hemophiliacs: Evidence for Heterosexual Transmission.
- J. K. KREISS, L. W. KITCHEN, H. E. PRINCE, C. K. KASPER, and M. ESSEX (1985)
Ann Intern Med
102, 623-626
| Abstract »
| PDF »
- Trans-acting transcriptional regulation of human T-cell leukemia virus type III long terminal repeat.
- J Sodroski, C Rosen, F Wong-Staal, S. Salahuddin, M Popovic, S Arya, R. Gallo, and W. Haseltine (1985)
Science
227, 171-173
| Abstract »
| PDF »
- Molecular characterization of human T-cell leukemia (lymphotropic) virus type III in the acquired immune deficiency syndrome.
- G. Shaw, B. Hahn, S. Arya, J. Groopman, R. Gallo, and F Wong-Staal (1984)
Science
226, 1165-1171
| Abstract »
| PDF »
- HTLV-III in saliva of people with AIDS-related complex and healthy homosexual men at risk for AIDS.
- J. Groopman, S. Salahuddin, M. Sarngadharan, P. Markham, M Gonda, A Sliski, and R. Gallo (1984)
Science
226, 447-449
| Abstract »
| PDF »
- HTLV-III in cells cultured from semen of two patients with AIDS.
- D Zagury, J Bernard, J Leibowitch, B Safai, J. Groopman, M Feldman, M. Sarngadharan, and R. Gallo (1984)
Science
226, 449-451
| Abstract »
| PDF »
- HTLV-III in the semen and blood of a healthy homosexual man.
- D. Ho, R. Schooley, T. Rota, J. Kaplan, T Flynn, S. Salahuddin, M. Gonda, and M. Hirsch (1984)
Science
226, 451-453
| Abstract »
| PDF »
- The Acquired Immunodeficiency Syndrome: Commentary.
- Council on Scientific Affairs (1984)
JAMA
252, 2037-2043
| Abstract »
| PDF »
|
|
