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Science 6 July 1984:
Vol. 225. no. 4657, pp. 80 - 82
DOI: 10.1126/science.6729469
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Articles

Science, Vol 225, Issue 4657, 80-82
Copyright © 1984 by American Association for the Advancement of Science

articles

Postnatal modification of hippocampal circuitry alters avoidance learning in adult rats

HP Lipp, H Schwegler, and P Driscoll

In rats and mice, the genetically mediated extent of the mossy fiber projection that synapses on the basal dendrites of hippocampal pyramidal cells is inversely correlated with rate of two-way avoidance (shuttle-box) learning. Postnatal hyperthyroidism, induced in 51 rat pups, resulted in marked variations of this infrapyramidal mossy fiber projection. The number of trials required for criterion performance of these rats in adulthood remained correlated with the neuroanatomical trait (r = 0.74, P less than 0.0001).


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Progressive decline in avoidance learning paralleled by inflammatory neurodegeneration in transgenic mice expressing interleukin 6 in the brain.
C. J. Heyser, E. Masliah, A. Samimi, I. L. Campbell, and L. H. Gold (1997)
PNAS 94, 1500-1505
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