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Science 6 July 1984:
Vol. 225. no. 4657, pp. 76 - 78
DOI: 10.1126/science.6328664
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Articles

Science, Vol 225, Issue 4657, 76-78
Copyright © 1984 by American Association for the Advancement of Science

articles

Phencyclidine-induced immunodepression

N Khansari, HD Whitten, and HH Fudenberg

Phencyclidine ("PCP" or "angel dust") and some of its derivatives are psychotomimetic drugs that have been used in general anesthesia for some time. This drug blocks potassium ion channels in brain tissue, and there is a specific PCP binding to lymphocytes. In a study of the effects of this drug on immunocyte function, it was found that humoral and cellular immune responses in vitro were depressed when immunocytes were treated with PCP before biological assay. This finding has implications for PCP abuse and also for the use of its derivative in general anesthesia, where it may contribute to postoperative infection.


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Metabolism of Phencyclidine by Human Liver Microsomes.
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