Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 6 July 1984:
Vol. 225. no. 4657, pp. 59 - 63
DOI: 10.1126/science.6328660
Prev | Table of Contents | Next

Articles

Science, Vol 225, Issue 4657, 59-63
Copyright © 1984 by American Association for the Advancement of Science

articles

Selective tropism of lymphadenopathy associated virus (LAV) for helper-inducer T lymphocytes

D Klatzmann, F Barre-Sinoussi, MT Nugeyre, C Danquet, E Vilmer, C Griscelli, F Brun-Veziret, C Rouzioux, JC Gluckman, JC Chermann, and al. et

Lymphadenopathy associated virus ( LAV ) has been isolated from patients with the acquired immunodeficiency syndrome (AIDS) or lymphadenopathy syndrome. Since the immune deficiency in AIDS seems to be primarily related to the defect of the helper-inducer T lymphocyte subset, the possibility that LAV is selectively tropic for this subset was investigated. Fractionation of T lymphocytes was achieved by cellular affinity chromatography with monoclonal antibodies. In a hemophilic patient who was a healthy carrier of LAV , reverse transcriptase activity and virus particles detected by electron microscopy were found only in cultures of helper-inducer lymphocytes. When infected with LAV in vitro, lymphocyte subsets from normal individuals yielded similar results. Virus production was associated with impaired proliferation, modulation of T3-T4 cell markers, and the appearance of cytopathic effects. The results provide evidence for the involvement of LAV in AIDS.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
HIV Pathogenesis: Knowledge Gained after Two Decades of Research.
J.A. Levy (2006)
Advances in Dental Research 19, 10-16
   Abstract »    Full Text »    PDF »
Characterization and role of lentivirus-associated host proteins..
K. Kolegraff, P. Bostik, and A. A. Ansari (2006)
Experimental Biology and Medicine 231, 252-263
   Abstract »    Full Text »    PDF »
An Unrelated Monoclonal Antibody Neutralizes Human Immunodeficiency Virus Type 1 by Binding to an Artificial Epitope Engineered in a Functionally Neutral Region of the Viral Envelope Glycoproteins.
X. Ren, J. Sodroski, and X. Yang (2005)
J. Virol. 79, 5616-5624
   Abstract »    Full Text »    PDF »
Extracellular Nef Protein Targets CD4+ T Cells for Apoptosis by Interacting with CXCR4 Surface Receptors.
C. O. James, M.-B. Huang, M. Khan, M. Garcia-Barrio, M. D. Powell, and V. C. Bond (2004)
J. Virol. 78, 3099-3109
   Abstract »    Full Text »    PDF »
The Stoichiometry of Trimeric SIV Glycoprotein Interaction with CD4 Differs from That of Anti-envelope Antibody Fab Fragments.
M. Kim, B. Chen, R. E. Hussey, Y. Chishti, D. Montefiori, J. A. Hoxie, O. Byron, G. Campbell, S. C. Harrison, and E. L. Reinherz (2001)
J. Biol. Chem. 276, 42667-42676
   Abstract »    Full Text »    PDF »
Differential Incorporation of CD45, CD80 (B7-1), CD86 (B7-2), and Major Histocompatibility Complex Class I and II Molecules into Human Immunodeficiency Virus Type 1 Virions and Microvesicles: Implications for Viral Pathogenesis and Immune Regulation.
M. T. Esser, D. R. Graham, L. V. Coren, C. M. Trubey, J. W. Bess Jr., L. O. Arthur, D. E. Ott, and J. D. Lifson (2001)
J. Virol. 75, 6173-6182
   Abstract »    Full Text »    PDF »
CD8+ Lymphocytes from Simian Immunodeficiency Virus-Infected Rhesus Macaques Recognize 14 Different Epitopes Bound by the Major Histocompatibility Complex Class I Molecule Mamu-A*01: Implications for Vaccine Design and Testing.
T. M. Allen, B. R. Mothe, J. Sidney, P. Jing, J. L. Dzuris, M. E. Liebl, T. U. Vogel, D. H. O'Connor, X. Wang, M. C. Wussow, et al. (2001)
J. Virol. 75, 738-749
   Abstract »    Full Text »    PDF »
Conserved MHC Class I Peptide Binding Motif Between Humans and Rhesus Macaques.
J. L. Dzuris, J. Sidney, E. Appella, R. W. Chesnut, D. I. Watkins, and A. Sette (2000)
J. Immunol. 164, 283-291
   Abstract »    Full Text »    PDF »
Productive infection of double-negative T cells with HIV in vivo.
G. Marodon, D. Warren, M. C. Filomio, and D. N. Posnett (1999)
PNAS 96, 11958-11963
   Abstract »    Full Text »    PDF »
Synthetic Peptides Derived from the Variable Regions of an Anti-CD4 Monoclonal Antibody Bind to CD4 and Inhibit HIV-1 Promoter Activation in Virus-infected Cells.
C. Monnet, D. Laune, J. Laroche-Traineau, M. Biard-Piechaczyk, L. Briant, C. Bes, M. Pugniere, J.-C. Mani, B. Pau, M. Cerutti, et al. (1999)
J. Biol. Chem. 274, 3789-3796
   Abstract »    Full Text »    PDF »
Dendritic Cells Route Human Immunodeficiency Virus to Lymph Nodes after Vaginal or Intravenous Administration to Mice.
C. Masurier, B. Salomon, N. Guettari, C. Pioche, F. Lachapelle, M. Guigon, and D. Klatzmann (1998)
J. Virol. 72, 7822-7829
   Abstract »    Full Text »    PDF »
Characterization of the Peptide Binding Motif of a Rhesus MHC Class I Molecule (Mamu-A*01) That Binds an Immunodominant CTL Epitope from Simian Immunodeficiency Virus.
T. M. Allen, J. Sidney, M.-F. del Guercio, R. L. Glickman, G. L. Lensmeyer, D. A. Wiebe, R. DeMars, C. D. Pauza, R. P. Johnson, A. Sette, et al. (1998)
J. Immunol. 160, 6062-6071
   Abstract »    Full Text »    PDF »
The Lipophosphoglycan of Leishmania donovani Up-Regulates HIV-1 Transcription in T Cells Through the Nuclear Factor-{kappa}B Elements.
R. Bernier, B. Barbeau, M. J. Tremblay, and M. Olivier (1998)
J. Immunol. 160, 2881-2888
   Abstract »    Full Text »    PDF »
Loss of Inducible Virus in CD45RA Naive Cells After Human Immunodeficiency Virus-1 Entry Accounts for Preferential Viral Replication in CD45RO Memory Cells.
T. C. Woods, B. D. Roberts, S. T. Butera, and T. M. Folks (1997)
Blood 89, 1635-1641
   Abstract »    Full Text »    PDF »
Vaccines against Human Immunodeficiency Virus -- Progress and Prospects.
N. L. Letvin (1993)
N. Engl. J. Med. 329, 1400-1405
   Full Text »
How does HIV cause AIDS?.
R. Weiss (1993)
Science 260, 1273-1279
   Abstract »    PDF »
AIDS virus history.
J. Gluckman (1993)
Science 259, 1809
   PDF »
Expression directed from HIV long terminal repeats in the central nervous system of transgenic mice.
Corboy JR, J. Buzy, M. Zink, and J. Clements (1992)
Science 258, 1804-1808
   Abstract »    PDF »
Dendritic cells exposed to human immunodeficiency virus type-1 transmit a vigorous cytopathic infection to CD4+ T cells.
P. Cameron, P. Freudenthal, J. Barker, S Gezelter, K Inaba, and R. Steinman (1992)
Science 257, 383-387
   Abstract »    PDF »
LAV revisited: origins of the early HIV-1 isolates from Institut Pasteur.
S Wain-Hobson, J. Vartanian, M Henry, N Chenciner, R Cheynier, S Delassus, L. Martins, M Sala, M. Nugeyre, D Guetard, et al. (1991)
Science 252, 961-965
   Abstract »    PDF »
Immunopathogenic Mechanisms in Human Immunodeficiency Virus (HIV) Infection.
A. S. Fauci, S. M. Schnittman, G. Poli, S. Koenig, and G. Pantaleo (1991)
Ann Intern Med 114, 678-693
   Abstract »    PDF »
Immune Complexes in Pediatric Human Immunodeficiency Virus Infection.
M. Ellaurie, T. Calvelli, and A. Rubinstein (1990)
Arch Pediatr Adolesc Med 144, 1207-1209
   Abstract »    PDF »
Increasing Viral Burden in CD4+ T Cells from Patients with Human Immunodeficiency Virus (HIV) Infection Reflects Rapidly Progressive Immunosuppression and Clinical Disease.
S. M. Schnittman, J. J. Greenhouse, M. C. Psallidopoulos, M. Baseler, N. P. Salzman, A. S. Fauci, and H. C. Lane (1990)
Ann Intern Med 113, 438-443
   Abstract »    PDF »
The Safety and Pharmacokinetics of Recombinant Soluble CD4 (rCD4) in Subjects with the Acquired Immunodeficiency Syndrome (AIDS) and AIDS-Related Complex: A Phase 1 Study.
J. O. Kahn, J. D. Allan, T. L. Hodges, L. D. Kaplan, C. J. Arri, H. F. Fitch, A. E. Izu, J. Mordenti, S. A. Sherwin, J. E. Groopman, et al. (1990)
Ann Intern Med 112, 254-261
   Abstract »    PDF »
Allogeneic Bone Marrow Transplantation, Zidovudine, and Human Immunodeficiency Virus Type 1 (HIV-I) Infection: Studies in a Patient with Non-Hodgkin Lymphoma.
H. K. Holland, R. Saral, J. J. Rossi, A. D. Donnenberg, W. H. Burns, W. E. Beschorner, H. Farzadegan, R. J. Jones, G. V. Quinnan, G. B. Vogelsang, et al. (1989)
Ann Intern Med 111, 973-981
   Abstract »    PDF »
The reservoir for HIV-1 in human peripheral blood is a T cell that maintains expression of CD4.
S. Schnittman, M. Psallidopoulos, H. Lane, L Thompson, M Baseler, F Massari, C. Fox, N. Salzman, and A. Fauci (1989)
Science 245, 305-308
   Abstract »    PDF »
The Fc and not CD4 receptor mediates antibody enhancement of HIV infection in human cells.
J Homsy, M Meyer, M Tateno, S Clarkson, and J. Levy (1989)
Science 244, 1357-1360
   Abstract »    PDF »
Predictive Markers for the Acquired Immunodeficiency Syndrome (AIDS) in Hemophiliacs: Persistence of p24 Antigen and Low T4 Cell Count.
M. E. Eyster, J. O. Ballard, M. H. Gail, J. E. Drammond, and J. J. Goedert (1989)
Ann Intern Med 110, 963-969
   Abstract »    PDF »
Involvement of a leukocyte adhesion receptor (LFA-1) in HIV-induced syncytium formation.
J. Hildreth and R. Orentas (1989)
Science 244, 1075-1078
   Abstract »    PDF »
Human Immunodeficiency Viruses and the Pathogenesis of AIDS.
J. A. Levy (1989)
JAMA 261, 2997-3006
   Abstract »    PDF »
Development of disease and virus recovery in transgenic mice containing HIV proviral DNA.
J. Leonard, J. Abramczuk, D. Pezen, R Rutledge, J. Belcher, F Hakim, G Shearer, L Lamperth, W Travis, T Fredrickson, et al. (1988)
Science 242, 1665-1670
   Abstract »    PDF »
Unexpectedly high levels of HIV-1 RNA and protein synthesis in a cytocidal infection.
M Somasundaran and H. Robinson (1988)
Science 242, 1554-1557
   Abstract »    PDF »
Infection and replication of HIV-1 in purified progenitor cells of normal human bone marrow.
T. Folks, S. Kessler, J. Orenstein, J. Justement, E. Jaffe, and A. Fauci (1988)
Science 242, 919-922
   Abstract »    PDF »
Antibody-enhanced infection by HIV-1 via Fc receptor-mediated entry.
A Takeda, C. Tuazon, and F. Ennis (1988)
Science 242, 580-583
   Abstract »    PDF »
Development and testing of AIDS vaccines.
W. Koff and D. Hoth (1988)
Science 241, 426-432
   Abstract »    PDF »
The Transmission of AIDS: The Case of the Infected Cell.
J. A. Levy (1988)
JAMA 259, 3037-3038
   Abstract »    PDF »
Lymphoid Neoplasia Associated with the Acquired Immunodeficiency Syndrome (AIDS) The New York University Medical Center Experience with 105 Patients (1981-1986).
D. M. KNOWLES, G. A. CHAMULAK, M. SUBAR, J. S. BURKE, M. DUGAN, J. WERNZ, C. SLYWOTZKY, P. PELICCI, R. DALLA-FAVERA, and B. RAPHAEL (1988)
Ann Intern Med 108, 744-753
   Abstract »    PDF »
Characterization of the Acute Clinical Illness Associated With Human Immunodeficiency Virus Infection.
B. Tindall, S. Barker, B. Donovan, T. Barnes, J. Roberts, C. Kronenberg, J. Gold, R. Penny, D. Cooper, the Sydney AIDS Study Group, et al. (1988)
Arch Intern Med 148, 945-949
   Abstract »    PDF »
Letter to the Editor.
A. W. Hopefl, D. P. Kotler, M. E. Garcia, C. L. Collins, K. S. Blair, J. J. Mamel, N. Schafer, and G. Kitay (1988)
Nutr Clin Pract 3, 5-7
   PDF »
A quantitative bioassay for HIV-1 based on trans-activation.
B. Felber and G. Pavlakis (1988)
Science 239, 184-187
   Abstract »    PDF »
Blocking of HIV-1 infectivity by a soluble, secreted form of the CD4 antigen.
D. Smith, R. Byrn, S. Marsters, T Gregory, J. Groopman, and D. Capon (1987)
Science 238, 1704-1707
   Abstract »    PDF »
Cytokine-induced expression of HIV-1 in a chronically infected promonocyte cell line.
T. Folks, J Justement, A Kinter, C. Dinarello, and A. Fauci (1987)
Science 238, 800-802
   Abstract »    PDF »
Diagnosis of Human Immunodeficiency Virus Infection in Seronegative Homosexuals Presenting With an Acute Viral Syndrome.
H. A. Kessler, B. Blaauw, J. Spear, D. A. Paul, L. A. Falk, and A. Landay (1987)
JAMA 258, 1196-1199
   Abstract »    PDF »
Immunology of Human Immunodeficiency Virus Infection and the Acquired Immunodeficiency Syndrome: An Update.
M. SELIGMANN, A. J. PINCHING, F. S. ROSEN, J. L. FAHEY, R. M. KHAITOV, D. KLATZMANN, S. KOENIG, N. LUO, J. NGU, G. RIETHMULLER, et al. (1987)
Ann Intern Med 107, 234-242
   Abstract »    PDF »
Natural History of Human Immunodeficiency Virus Infections in Hemophiliacs: Effects of T-Cell Subsets, Platelet Counts, and Age.
M. E. EYSTER, M. H. GAIL, J. O. BALLARD, H. AL-MONDHIRY, and J. J. GOEDERT (1987)
Ann Intern Med 107, 1-6
   Abstract »    PDF »
Serologic and Immunologic Studies in Patients With AIDS in North America and Africa: The Potential Role of Infectious Agents as Cofactors in Human Immunodeficiency Virus Infection.
T. C. Quinn, P. Piot, J. B. McCormick, F. M. Feinsod, H. Taelman, B. Kapita, W. Stevens, and A. S. Fauci (1987)
JAMA 257, 2617-2621
   Abstract »    PDF »
Antibody Responses After Influenza and Pneumococcal Immunization in HIV-Infected Homosexual Men.
K.-L. Huang, F. L. Ruben, C. R. Rinaldo Jr, L. Kingsley, D. W. Lyter, and M. Ho (1987)
JAMA 257, 2047-2050
   Abstract »    PDF »
Immunomodulators in Clinical Medicine.
A. S. FAUCI, S. A. ROSENBERG, S. A. SHERWIN, C. A. DINARELLO, D. L. LONGO, and H. C. LANE (1987)
Ann Intern Med 106, 421-433
   Abstract »    PDF »
Effect of T4 Count and Cofactors on the Incidence of AIDS in Homosexual Men Infected With Human Immunodeficiency Virus.
J. J. Goedert, R. J. Biggar, M. Melbye, D. L. Mann, S. Wilson, M. H. Gail, R. J. Grossman, R. A. DiGioia, W. C. Sanchez, S. H. Weiss, et al. (1987)
JAMA 257, 331-334
   Abstract »    PDF »
CD8+ lymphocytes can control HIV infection in vitro by suppressing virus replication.
C. Walker, D. Moody, D. Stites, and J. Levy (1986)
Science 234, 1563-1566
   Abstract »    PDF »
Alterations in T4 (CD4) protein and mRNA synthesis in cells infected with HIV.
J. Hoxie, J. Alpers, J. Rackowski, K Huebner, B. Haggarty, A. Cedarbaum, and J. Reed (1986)
Science 234, 1123-1127
   Abstract »    PDF »
Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy.
S Koenig, H. Gendelman, J. Orenstein, M. Dal Canto, G. Pezeshkpour, M Yungbluth, F Janotta, A Aksamit, M. Martin, and A. Fauci (1986)
Science 233, 1089-1093
   Abstract »    PDF »
Isolation of a new human retrovirus from West African patients with AIDS.
F Clavel, D Guetard, F Brun-Vezinet, S Chamaret, M. Rey, M. Santos-Ferreira, A. Laurent, C Dauguet, C Katlama, C Rouzioux, et al. (1986)
Science 233, 343-346
   Abstract »    PDF »
Neutralization of the AIDS retrovirus by antibodies to a recombinant envelope glycoprotein.
L. Lasky, J. Groopman, C. Fennie, P. Benz, D. Capon, D. Dowbenko, G. Nakamura, W. Nunes, M. Renz, and P. Berman (1986)
Science 233, 209-212
   Abstract »    PDF »
The role of mononuclear phagocytes in HTLV-III/LAV infection.
S Gartner, P Markovits, D. Markovitz, M. Kaplan, R. Gallo, and M Popovic (1986)
Science 233, 215-219
   Abstract »    PDF »
Human T-Cell Lymphotropic Viruses: Syncytia Formation.
L. Resnick and G. Novatt (1986)
JAMA 255, 3421
   PDF »
AIDS retrovirus induced cytopathology: giant cell formation and involvement of CD4 antigen.
J. Lifson, G. Reyes, M. McGrath, B. Stein, and E. Engleman (1986)
Science 232, 1123-1127
   Abstract »    PDF »
Activation of the AIDS retrovirus promoter by the cellular transcription factor, Sp1.
K. Jones, J. Kadonaga, P. Luciw, and R Tjian (1986)
Science 232, 755-759
   Abstract »    PDF »
Stability and Inactivation of HTLV-III/LAV Under Clinical and Laboratory Environments.
L. Resnick, K. Veren, S. Z. Salahuddin, S. Tondreau, and P. D. Markham (1986)
JAMA 255, 1887-1891
   Abstract »    PDF »
A new HTLV-III/LAV protein encoded by a gene found in cytopathic retroviruses.
T. Lee, J. Coligan, J. Allan, M. McLane, J. Groopman, and M Essex (1986)
Science 231, 1546-1549
   Abstract »    PDF »
Replicative and cytopathic potential of HTLV-III/LAV with sor gene deletions.
J Sodroski, W. Goh, C Rosen, A Tartar, D Portetelle, A Burny, and W Haseltine (1986)
Science 231, 1549-1553
   Abstract »    PDF »
Identification of HTLV-III/LAV sor gene product and detection of antibodies in human sera.
N. Kan, G Franchini, F Wong-Staal, G. DuBois, W. Robey, J. Lautenberger, and T. Papas (1986)
Science 231, 1553-1555
   Abstract »    PDF »
Induction of HTLV-III/LAV from a nonvirus-producing T-cell line: implications for latency.
T Folks, D. Powell, M. Lightfoote, S Benn, M. Martin, and A. Fauci (1986)
Science 231, 600-602
   Abstract »    PDF »
Binding of HTLV-III/LAV to T4+ T cells by a complex of the 110K viral protein and the T4 molecule.
J. McDougal, M. Kennedy, J. Sligh, S. Cort, A Mawle, and J. Nicholson (1986)
Science 231, 382-385
   Abstract »    PDF »
The T4 Glycoprotein Is a Cell-surface Receptor for the AIDS Virus.
J.S. McDougal, P.J. Maddon, A.G. Dalgleish, P.R. Clapham, D.R. Littman, M. Godfrey, D.E. Maddon, L. Chess, R.A. Weiss, and R. Axel (1986)
Cold Spring Harb Symp Quant Biol 51, 703-711
   Abstract »    PDF »
A new HTLV-III/LAV encoded antigen detected by antibodies from AIDS patients.
J. Allan, J. Coligan, T. Lee, M. McLane, P. Kanki, J. Groopman, and M Essex (1985)
Science 230, 810-813
   Abstract »    PDF »
Lymphadenopathy-Associated Virus: From Molecular Biology to Pathogenicity.
L. MONTAGNIER (1985)
Ann Intern Med 103, 689-693
   Abstract »    PDF »
Infection by the Retrovirus Associated with the Acquired Immunodeficiency Syndrome: Clinical, Biological, and Molecular Features.
J. A. LEVY, L. S. KAMINSKY, W. J. W. MORROW, K. STEIMER, P. LUCIW, D. DINA, J. HOXIE, and L. OSHIRO (1985)
Ann Intern Med 103, 694-699
   Abstract »    PDF »
Immunopathogenesis of the Acquired Immunodeficiency Syndrome.
D. L. BOWEN, H. C. LANE, and A. S. FAUCI (1985)
Ann Intern Med 103, 704-709
   Abstract »    PDF »
The Natural History of Infection with the Lymphadenopathy-Associated Virus Human T-Lymphotropic Virus Type III.
D. P. FRANCIS, H. W. JAFFE, P. N. FULTZ, J. P. GETCHELL, J. S. McDOUGAL, and P. M. FEORINO (1985)
Ann Intern Med 103, 719-722
   Abstract »    PDF »
Persistent noncytopathic infection of normal human T lymphocytes with AIDS-associated retrovirus.
J. Hoxie, B. Haggarty, J. Rackowski, N Pillsbury, and J. Levy (1985)
Science 229, 1400-1402
   Abstract »    PDF »
Infection of HTLV-III/LAV in HTLV-I-carrying cells MT-2 and MT-4 and application in a plaque assay.
S Harada, Y Koyanagi, and N Yamamoto (1985)
Science 229, 563-566
   Abstract »    PDF »
Trans-activator gene of human T-lymphotropic virus type III (HTLV-III).
S. Arya, C Guo, S. Josephs, and F Wong-Staal (1985)
Science 229, 69-73
   Abstract »    PDF »
AIDS Serology Testing in Low- and High-Risk Groups.
J. R. Carlson, M. L. Bryant, S. H. Hinrichs, J. K. Yamamoto, N. B. Levy, J. Yee, J. Higgins, A. M. Levine, P. Holland, M. B. Gardner, et al. (1985)
JAMA 253, 3405-3408
   Abstract »    PDF »
Human T-Lymphotropic Retrovirus Type III / Lymphadenopathy-Associated Virus Antibody: Association With Hemophiliacs' Immune Status and Blood Component Usage.
J. Jason, J. S. McDougal, R. C. Holman, S. F. Stein, D. N. Lawrence, J. K. A. Nicholson, G. Dixon, M. Doxey, B. L. Evatt, and the Hemophilia/AIDS Collaborative Study Group (1985)
JAMA 253, 3409-3415
   Abstract »    PDF »
Isolation of T-cell tropic HTLV-III-like retrovirus from macaques.
M. Daniel, N. Letvin, N. King, M Kannagi, P. Sehgal, R. Hunt, P. Kanki, M Essex, and R. Desrosiers (1985)
Science 228, 1201-1204
   Abstract »    PDF »
The Acquired Immunodeficiency Syndrome: An Update.
A. S. FAUCI, H. MASUR, E. P. GELMANN, P. D. MARKHAM, B. H. HAHN, and H. C. LANE (1985)
Ann Intern Med 102, 800-813
   Abstract »    PDF »
Expression in Escherichia coli of open reading frame gene segments of HTLV-III.
N. Chang, P. Chanda, A. Barone, S McKinney, D. Rhodes, S. Tam, C. Shearman, J Huang, T. Chang, R. Gallo, et al. (1985)
Science 228, 93-96
   Abstract »    PDF »
Immunoglobulin G Antibodies to Lymphadenopathy-Associated Virus in Differently Treated French and Belgian Hemophiliacs.
Ch. ROUZIOUX, F. BRUN-VEZINET, A.M. COUROUCE, C. GAZENGEL, D. VERGOZ, J. DESMYTER, J. VERMYLEN, C. VERMYLEN, D. KLATZMANN, D. GEROLDI, et al. (1985)
Ann Intern Med 102, 476-479
   Abstract »    PDF »
Isolation of Lymphadenopathy-Associated Virus (LAV) and Detection of LAV Antibodies From US Patients With AIDS.
F. Barre-Sinoussi, U. Mathur-Wagh, F. Rey, F. Brun-Vezinet, S. R. Yancovitz, C. Rouzioux, L. Montagnier, D. Mildvan, and J. C. Chermann (1985)
JAMA 253, 1737-1739
   Abstract »    PDF »
Nucleotide sequence and expression of an AIDS-associated retrovirus (ARV-2).
R Sanchez-Pescador, M. Power, P. Barr, K. Steimer, M. Stempien, S. Brown-Shimer, W. Gee, A Renard, A Randolph, J. Levy, et al. (1985)
Science 227, 484-492
   Abstract »    PDF »
Prevalence of antibodies to lymphadenopathy-associated retrovirus in African patients with AIDS.
F Brun-Vezinet, C Rouzioux, L Montagnier, S Chamaret, J Gruest, F Barre-Sinoussi, D Geroldi, J. Chermann, J McCormick, S Mitchell, et al. (1984)
Science 226, 453-456
   Abstract »    PDF »
The Acquired Immunodeficiency Syndrome: Commentary.
Council on Scientific Affairs (1984)
JAMA 252, 2037-2043
   Abstract »    PDF »
Adaptation of lymphadenopathy associated virus (LAV) to replication in EBV-transformed B lymphoblastoid cell lines.
L Montagnier, J Gruest, S Chamaret, C Dauguet, C Axler, D Guetard, M. Nugeyre, F Barre-Sinoussi, J. Chermann, J. Brunet, et al. (1984)
Science 225, 63-66
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)