Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 29 June 1984:
Vol. 224. no. 4656, pp. 1449 - 1451
DOI: 10.1126/science.6328656
Prev | Table of Contents | Next

Articles

Science, Vol 224, Issue 4656, 1449-1451
Copyright © 1984 by American Association for the Advancement of Science

articles

Corticotropin-releasing factor receptors in rat forebrain: autoradiographic identification

EB De Souza, MH Perrin, TR Insel, J Rivier, WW Vale, and MJ Kuhar

Corticotropin-releasing factor (CRF) receptors were identified in rat forebrain by autoradiography with an iodine-125-labeled analog of ovine CRF substituted with norleucine and tyrosine at amino acid residues 21 and 32, respectively. High-affinity receptors for CRF were found in discrete areas of rat forebrain, including laminae I and IV of the neocortex, the external layer of the medium eminence, the lateral nucleus of the amygdala, and the striatum. These results are consistent with earlier findings on the immunohistochemical distribution of CRF and suggest that endogenous CRF has a physiological role in regulating activity of the central nervous system.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
International Union of Pharmacology. XXXVI. Current Status of the Nomenclature for Receptors for Corticotropin-Releasing Factor and Their Ligands.
R. L. Hauger, D. E. Grigoriadis, M. F. Dallman, P. M. Plotsky, W. W. Vale, and F. M. Dautzenberg (2003)
Pharmacol. Rev. 55, 21-26
   Abstract »    Full Text »    PDF »
The Corticotropin-Release Inhibitory Factor Hypothesis: A Review of the Evidence for the Existence of Inhibitory as Well as Stimulatory Hypophysiotropic Regulation of Adrenocorticotropin Secretion and Biosynthesis.
D. Engler, E. Redei, and I. Kola (1999)
Endocr. Rev. 20, 460-500
   Abstract »    Full Text »    PDF »
Corticotropin-Releasing Factor Type 1 and Type 2{alpha} Receptors Regulate Phosphorylation of Calcium/Cyclic Adenosine 3',5'-Monophosphate Response Element-Binding Protein and Activation of p42/p44 Mitogen-Activated Protein Kinase.
C. J. Rossant, R. D. Pinnock, J. Hughes, M. D. Hall, and S. McNulty (1999)
Endocrinology 140, 1525-1536
   Abstract »    Full Text »
Comparison of an Agonist, Urocortin, and an Antagonist, Astressin, as Radioligands for Characterization of Corticotropin-Releasing Factor Receptors.
M. H. Perrin, S. W. Sutton, L. A. Cervini, J. E. Rivier, and W. W. Vale (1999)
J. Pharmacol. Exp. Ther. 288, 729-734
   Abstract »    Full Text »
Role of the Septum in the Excitatory Effect of Corticotropin-Releasing Hormone on the Acoustic Startle Reflex.
Y. Lee and M. Davis (1997)
J. Neurosci. 17, 6424-6433
   Abstract »    Full Text »    PDF »
Role of the Hippocampus, the Bed Nucleus of the Stria Terminalis, and the Amygdala in the Excitatory Effect of Corticotropin-Releasing Hormone on the Acoustic Startle Reflex.
Y. Lee and M. Davis (1997)
J. Neurosci. 17, 6434-6446
   Abstract »    Full Text »    PDF »
Corticotrophin releasing factor--a peptide link between stress and psychopathology associated with epilepsy?.
R. E. Adamec (1991)
J Psychopharmacol 5, 96-104
   Abstract »    PDF »
The effects of corticotrophin releasing factor (CRF) and handling stress on behavior in the elevated plus-maze test of anxiety.
R. E. Adamec, U. Sayin, and A. Brown (1991)
J Psychopharmacol 5, 175-186
   Abstract »    PDF »
Central and Peripheral ACTH and Cortisol Levels in Anorexia Nervosa and Bulimia.
H. E. Gwirtsman, W. H. Kaye, D. T. George, D. C. Jimerson, M. H. Ebert, and P. W. Gold (1989)
Arch Gen Psychiatry 46, 61-69
   Abstract »    PDF »
Corticotropin-Releasing Factor-like Immunoreactivity in Senile Dementia of the Alzheimer Type: Reduced Cortical and Striatal Concentrations.
G. Bissette, G. P. Reynolds, C. D. Kilts, E. Widerlov, and C. B. Nemeroff (1985)
JAMA 254, 3067-3069
   Abstract »    PDF »
Clinical Applications of Corticotropin-Releasing Factor.
G. P. CHROUSOS, T. H. SCHUERMEYER, J. DOPPMAN, E. H. OLDFIELD, H. M. SCHULTE, P. W. GOLD, and D. L. LORIAUX (1985)
Ann Intern Med 102, 344-358
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)