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Science 29 June 1984:
Vol. 224. no. 4656, pp. 1449 - 1451
DOI: 10.1126/science.6328656
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Articles
Science, Vol 224, Issue 4656, 1449-1451
Copyright © 1984 by American Association for the Advancement of Science
Corticotropin-releasing factor receptors in rat forebrain: autoradiographic identification
EB De Souza,
MH Perrin,
TR Insel,
J Rivier,
WW Vale,
and
MJ Kuhar
Corticotropin-releasing factor (CRF) receptors were identified in rat forebrain by autoradiography with an iodine-125-labeled analog of ovine CRF substituted with norleucine and tyrosine at amino acid residues 21 and 32, respectively. High-affinity receptors for CRF were found in discrete areas of rat forebrain, including laminae I and IV of the neocortex, the external layer of the medium eminence, the lateral nucleus of the amygdala, and the striatum. These results are consistent with earlier findings on the immunohistochemical distribution of CRF and suggest that endogenous CRF has a physiological role in regulating activity of the central nervous system.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- International Union of Pharmacology. XXXVI. Current Status of the Nomenclature for Receptors for Corticotropin-Releasing Factor and Their Ligands.
- R. L. Hauger, D. E. Grigoriadis, M. F. Dallman, P. M. Plotsky, W. W. Vale, and F. M. Dautzenberg (2003)
Pharmacol. Rev.
55, 21-26
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- The Corticotropin-Release Inhibitory Factor Hypothesis: A Review of the Evidence for the Existence of Inhibitory as Well as Stimulatory Hypophysiotropic Regulation of Adrenocorticotropin Secretion and Biosynthesis.
- D. Engler, E. Redei, and I. Kola (1999)
Endocr. Rev.
20, 460-500
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- Corticotropin-Releasing Factor Type 1 and Type 2{alpha} Receptors Regulate Phosphorylation of Calcium/Cyclic Adenosine 3',5'-Monophosphate Response Element-Binding Protein and Activation of p42/p44 Mitogen-Activated Protein Kinase.
- C. J. Rossant, R. D. Pinnock, J. Hughes, M. D. Hall, and S. McNulty (1999)
Endocrinology
140, 1525-1536
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- Comparison of an Agonist, Urocortin, and an Antagonist, Astressin, as Radioligands for Characterization of Corticotropin-Releasing Factor Receptors.
- M. H. Perrin, S. W. Sutton, L. A. Cervini, J. E. Rivier, and W. W. Vale (1999)
J. Pharmacol. Exp. Ther.
288, 729-734
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- Role of the Septum in the Excitatory Effect of Corticotropin-Releasing Hormone on the Acoustic Startle Reflex.
- Y. Lee and M. Davis (1997)
J. Neurosci.
17, 6424-6433
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- Role of the Hippocampus, the Bed Nucleus of the Stria Terminalis, and the Amygdala in the Excitatory Effect of Corticotropin-Releasing Hormone on the Acoustic Startle Reflex.
- Y. Lee and M. Davis (1997)
J. Neurosci.
17, 6434-6446
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- Corticotrophin releasing factor--a peptide link between stress and psychopathology associated with epilepsy?.
- R. E. Adamec (1991)
J Psychopharmacol
5, 96-104
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- The effects of corticotrophin releasing factor (CRF) and handling stress on behavior in the elevated plus-maze test of anxiety.
- R. E. Adamec, U. Sayin, and A. Brown (1991)
J Psychopharmacol
5, 175-186
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