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Science 29 June 1984:
Vol. 224. no. 4656, pp. 1445 - 1447
DOI: 10.1126/science.6328655
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Articles

Science, Vol 224, Issue 4656, 1445-1447
Copyright © 1984 by American Association for the Advancement of Science

articles

Human colon cells: culture and in vitro transformation

MP Moyer and JB Aust

Normal human colon mucosal epithelial cells were cultured in vitro and treated with the oncogenic simian DNA virus (SV40) and the chemical carcinogen azoxymethane. Both SV40 and azoxymethane altered a number of phenotypic characteristics of the normal human colon cells, including their morphology, culture longevity, growth in soft agar, substrate adherence, and peanut agglutinin binding. The SV40 transformants synthesized intranuclear T antigen. These data indicate that normal human colon mucosal cells were transformed toward the malignant phenotype.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Neoplastic conversion of human keratinocytes by adenovirus 12-SV40 virus and chemical carcinogens.
J. Rhim, J Fujita, P Arnstein, and S. Aaronson (1986)
Science 232, 385-388
   Abstract »    PDF »
Effects of Gastrin, Glutamine, and Somatostatin on the In Vitro Growth of Normal and Malignant Human Gastric Mucosal Cells.
M. P. Moyer, A. Armstrong, J. B. Aust, B. A. Levine, and K. R. Sirinek (1986)
Arch Surg 121, 285-288
   Abstract »    PDF »


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