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Science 29 June 1984:
Vol. 224. no. 4656, pp. 1443 - 1445
DOI: 10.1126/science.224.4656.1443
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Articles

Acetolactate Synthase Is the Site of Action of Two Sulfonylurea Herbicides in Higher Plants

R. S. CHALEFF 1 and C. J. MAUVAIS 1

1 Department of Central Research and Development, Experimental Station, E. I. du Pont de Nemours and Company, Wilimington, Delaware 19898

Biochemical and genetic studies of a tobacco mutant resistant to the herbicides chlorsulfuron and sulfometuron methyl have demonstrated that these sulfonylurea herbicides inhibit acetolactate synthase, the first enzyme specific to the branched chain amino acid biosynthetic pathway. Resistance of this mutant is accomplished by production of a form of the enzyme that is insensitive to inhibition by the two herbicides.

Submitted on February 6, 1984
Accepted on April 19, 1984


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Targeted manipulation of maize genes in vivo using chimeric RNA/DNA oligonucleotides.
T. Zhu, D. J. Peterson, L. Tagliani, G. St. Clair, C. L. Baszczynski, and B. Bowen (1999)
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