Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 29 June 1984:
Vol. 224. no. 4656, pp. 1392 - 1398
DOI: 10.1126/science.6729459
Prev | Table of Contents | Next

Articles

Science, Vol 224, Issue 4656, 1392-1398
Copyright © 1984 by American Association for the Advancement of Science

articles

Blood pressure and nutrient intake in the United States

DA McCarron, CD Morris, HJ Henry, and JL Stanton

A data base of the National Center for Health Statistics, Health and Nutrition Examination Survey I (HANES I), was used to perform a computer-assisted, comprehensive analysis of the relation of 17 nutrients to the blood pressure profile of adult Americans. Subjects were 10,372 individuals, 18 to 74 years of age, who denied a history of hypertension and intentional modification of their diet. Significant decreases in the consumption of calcium, potassium, vitamin A, and vitamin C were identified as the nutritional factors that distinguished hypertensive from normotensive subjects. Lower calcium intake was the most consistent factor in hypertensive individuals. Across the population, higher intakes of calcium, potassium, and sodium were associated with lower mean systolic blood pressure and lower absolute risk of hypertension. Increments of dietary calcium were also negatively correlated with body mass. Even though these correlations cannot be accepted as proof of causation, they have implications for future studies of the association of nutritional factors and dietary patterns with hypertension in America.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Oxidative Stress in Prehypertension: Rationale for Antioxidant Clinical Trials.
S. Nambiar, S. Viswanathan, B. Zachariah, N. Hanumanthappa, and Sridhar Gopalakrishna Magadi (2009)
Angiology 60, 221-234
   Abstract »    PDF »
Urinary Potassium Is a Clinically Useful Test to Detect a Poor Quality Diet.
A. Mente, E. J. Irvine, R. J. DA. Honey, and A. G. Logan (2009)
J. Nutr. 139, 743-749
   Abstract »    Full Text »    PDF »
Association of the Calcium-Sensing Receptor Gene with Blood Pressure and Urinary Calcium in African-Americans.
J. Jung, T. M. Foroud, G. J. Eckert, L. Flury-Wetherill, H. J. Edenberg, X. Xuei, S.-A. Zaidi, and J. H. Pratt (2009)
J. Clin. Endocrinol. Metab. 94, 1042-1048
   Abstract »    Full Text »    PDF »
Milk Products, Dietary Patterns and Blood Pressure Management.
P. M. Kris-Etherton, J. A. Grieger, K. F. Hilpert, and S. G. West (2009)
J. Am. Coll. Nutr. 28, 103S-119S
   Abstract »    Full Text »    PDF »
The Role of Dairy Foods and Dietary Calcium in Weight Management.
M. Van Loan (2009)
J. Am. Coll. Nutr. 28, 120S-129S
   Abstract »    Full Text »    PDF »
Dairy Intake and Anthropometric Measures of Body Fat among Children and Adolescents in NHANES.
L. L. Moore, M. R. Singer, M. M. Qureshi, and M. L. Bradlee (2008)
J. Am. Coll. Nutr. 27, 702-710
   Abstract »    Full Text »    PDF »
Review of the Effect of Dairy Products on Non-Lipid Risk Factors for Cardiovascular Disease.
B. Lamarche (2008)
J. Am. Coll. Nutr. 27, 741S-746S
   Abstract »    Full Text »    PDF »
Salt intake and cardiovascular disease.
F. J. He, G. A. MacGregor, and D. A. McCarron (2008)
Nephrol. Dial. Transplant. 23, 3382-3385
   Full Text »    PDF »
Dietary sodium and cardiovascular and renal disease risk factors: dark horse or phantom entry?.
D. A. McCarron (2008)
Nephrol. Dial. Transplant. 23, 2133-2137
   Full Text »    PDF »
Association of Calcium Intake and Adiposity in Postmenopausal Women.
C. J. Heiss, S. E. Shaw, and L. Carothers (2008)
J. Am. Coll. Nutr. 27, 260-266
   Abstract »    Full Text »    PDF »
Pharmacological Treatment of the Overweight Patient.
G. A. Bray and F. L. Greenway (2007)
Pharmacol. Rev. 59, 151-184
   Full Text »    PDF »
The Effects of Calcium and Vitamin D Supplementation on Blood Glucose and Markers of Inflammation in Nondiabetic Adults.
A. G. Pittas, S. S. Harris, P. C. Stark, and B. Dawson-Hughes (2007)
Diabetes Care 30, 980-986
   Abstract »    Full Text »    PDF »
Milk Peptides and Blood Pressure.
T. Jauhiainen and R. Korpela (2007)
J. Nutr. 137, 825S-829S
   Abstract »    Full Text »    PDF »
Association of Calcium Intake, Dairy Product Consumption with Overweight Status in Young Adults (1995-1996): The Bogalusa Heart Study.
B.M. Brooks, R. Rajeshwari, T. A. Nicklas, S.-J. Yang, and G. S. Berenson (2006)
J. Am. Coll. Nutr. 25, 523-532
   Abstract »    Full Text »    PDF »
Major scientific advances with dairy foods in nutrition and health..
P. J. Huth, D. B. DiRienzo, and G. D. Miller (2006)
J Dairy Sci 89, 1207-1221
   Abstract »    Full Text »    PDF »
Reducing Hypertensive Cardiovascular Disease Risk of African Americans with Diet: Focus on the Facts.
M. E. Reusser and D. A. McCarron (2006)
J. Nutr. 136, 1099-1102
   Abstract »    Full Text »    PDF »
The Influence of Dairy Product Consumption on Body Composition.
D. Teegarden (2005)
J. Nutr. 135, 2749-2752
   Abstract »    Full Text »    PDF »
Dairy consumption is inversely associated with the prevalence of the metabolic syndrome in Tehranian adults.
L. Azadbakht, P. Mirmiran, A. Esmaillzadeh, and F. Azizi (2005)
Am. J. Clinical Nutrition 82, 523-530
   Abstract »    Full Text »    PDF »
Dietary Calcium, Obesity and Hypertension--The End of the Road?.
K. Sakhaee and N. M. Maalouf (2005)
J. Clin. Endocrinol. Metab. 90, 4411-4413
   Full Text »    PDF »
Effects of Calcium Supplementation on Body Weight and Blood Pressure in Normal Older Women: A Randomized Controlled Trial.
I. R. Reid, A. Horne, B. Mason, R. Ames, U. Bava, and G. D. Gamble (2005)
J. Clin. Endocrinol. Metab. 90, 3824-3829
   Abstract »    Full Text »    PDF »
No effect of dietary calcium on body weight of lean and obese mice and rats.
Q. Zhang and M. G. Tordoff (2004)
Am J Physiol Regulatory Integrative Comp Physiol 286, R669-R677
   Abstract »    Full Text »    PDF »
Effect of Calcium Supplementation on Weight and Fat Loss in Women.
S. A. Shapses, S. Heshka, and S. B. Heymsfield (2004)
J. Clin. Endocrinol. Metab. 89, 632-637
   Abstract »    Full Text »    PDF »
Bovine lactoferrin has a nitric oxide-dependent hypotensive effect in rats.
K.-i. Hayashida, T. Takeuchi, T. Ozaki, H. Shimizu, K. Ando, A. Miyamoto, and E. Harada (2004)
Am J Physiol Regulatory Integrative Comp Physiol 286, R359-R365
   Abstract »    Full Text »    PDF »
Does whole body autoregulation mediate the hemodynamic responses to increased dietary salt in rats with clamped ANG II?.
D. M. Fine, P. Ariza-Nieto, and J. W. Osborn (2003)
Am J Physiol Heart Circ Physiol 285, H2670-H2678
   Abstract »    Full Text »    PDF »
Calcium intake, body composition, and lipoprotein-lipid concentrations in adults.
M. Jacqmain, E. Doucet, J.-P. Despres, C. Bouchard, and A. Tremblay (2003)
Am. J. Clinical Nutrition 77, 1448-1452
   Abstract »    Full Text »    PDF »
Intakes of Calcium and Vitamin D Predict Body Mass Index in the Population of Northern Norway.
E. Kamycheva, R. M. Joakimsen, and R. Jorde (2003)
J. Nutr. 133, 102-106
   Abstract »    Full Text »    PDF »
Serum Antioxidant Vitamins and Blood Pressure in the United States Population.
J. Chen, J. He, L. Hamm, V. Batuman, and P. K. Whelton (2002)
Hypertension 40, 810-816
   Abstract »    Full Text »    PDF »
Regulation of Adiposity and Obesity Risk By Dietary Calcium: Mechanisms and Implications.
M. B. Zemel (2002)
J. Am. Coll. Nutr. 21, 146S-151
   Abstract »    Full Text »    PDF »
Calcium Modulation of Hypertension and Obesity: Mechanisms and Implications.
M. B. Zemel (2001)
J. Am. Coll. Nutr. 20, 428S-435
   Abstract »    Full Text »
Dietary Sodium and Blood Pressure.
M. Alderman, D. A. McCarron, D. B. Petitti, D. Freedman, C. Bartlett, L. Hooper, S. Ebrahim, F. M. Sacks, M. A. Proschan, L. P. Svetkey, et al. (2001)
N. Engl. J. Med. 344, 1716-1719
   Full Text »    PDF »
Reply to P Strazzullo.
D. A McCarron (2001)
Am. J. Clinical Nutrition 73, 663-664
   Full Text »    PDF »
Impact of Diet on Blood Pressure and Age-Related Changes in Blood Pressure in the US Population: Analysis of NHANES III.
I. M. Hajjar, C. E. Grim, V. George, and T. A. Kotchen (2001)
Arch Intern Med 161, 589-593
   Abstract »    Full Text »    PDF »
Effect of ascorbic acid treatment on conduit vessel endothelial dysfunction in patients with hypertension.
S. J. Duffy, N. Gokce, M. Holbrook, L. M. Hunter, E. S. Biegelsen, A. Huang, J. F. Keaney Jr., and J. A. Vita (2001)
Am J Physiol Heart Circ Physiol 280, H528-H534
   Abstract »    Full Text »    PDF »
Calcium Intake and Body Weight.
K. M. Davies, R. P. Heaney, R. R. Recker, J. M. Lappe, M. J. Barger-Lux, K. Rafferty, and S. Hinders (2000)
J. Clin. Endocrinol. Metab. 85, 4635-4638
   Abstract »    Full Text »
Isolation and Characterization of Coenzyme A Glutathione Disulfide as a Parathyroid-Derived Vasoconstrictive Factor.
J. Jankowski, A. Schroter, M. Tepel, M. van der Giet, N. Stephan, J. Luo, W. Zidek, and H. Schluter (2000)
Circulation 102, 2548-2552
   Abstract »    Full Text »    PDF »
Calcium from dairy products, vitamin D intake, and blood pressure: the Tromso study.
R. Jorde and K. H Bonaa (2000)
Am. J. Clinical Nutrition 71, 1530-1535
   Abstract »    Full Text »    PDF »
Benefits of Dairy Product Consumption on Blood Pressure in Humans: A Summary of the Biomedical Literature.
G. D. Miller, D. D. DiRienzo, M. E. Reusser, and D. A. McCarron (2000)
J. Am. Coll. Nutr. 19, 147S-164
   Abstract »    Full Text »    PDF »
Finding Consensus in the Dietary Calcium-Blood Pressure Debate.
D. A. McCarron and M. E. Reusser (1999)
J. Am. Coll. Nutr. 18, 398S-405
   Abstract »    Full Text »    PDF »
Comparison of the effects of supplementation with whey mineral and potassium on arterial tone in experimental hypertension.
X. Wu, J.-P. Tolvanen, N. Hutri-Kahonen, M. Kahonen, H. Makynen, R. Korpela, H. Ruskoaho, K. Karjala, and I. Porsti (1998)
Cardiovasc Res 40, 364-374
   Abstract »    Full Text »    PDF »
Dietary Electrolytes and Blood Pressure : A Statement for Healthcare Professionals From the American Heart Association Nutrition Committee.
T. A. Kotchen and D. A. McCarron (1998)
Circulation 98, 613-617
   Full Text »    PDF »
Calcium-Regulated Renal Calcium Handling in Healthy Men: Relationship to Sodium Handling.
G. El-Hajj Fuleihan, J. Seifter, J. Scott, and E. M. Brown (1998)
J. Clin. Endocrinol. Metab. 83, 2366-2372
   Abstract »    Full Text »
Dietary Calcium and Blood Pressure in a Native American Population.
K.M. V. Narayan, R. L. Hanson, C. J. Smith, R. G. Nelson, S. B. Gyenizse, D. J. Pettitt, and W. C. Knowler (1998)
J. Am. Coll. Nutr. 17, 59-64
   Abstract »    Full Text »    PDF »
Importance of Dietary Calcuim in Hypertension.
D. A. McCarron and H. G. Preuss (1998)
J. Am. Coll. Nutr. 17, 97-98
   Full Text »    PDF »
Calcium and Magnesium in Drinking Water and Risk of Death From Cerebrovascular Disease.
C.-Y. Yang (1998)
Stroke 29, 411-414
   Abstract »    Full Text »    PDF »
Dietary Patterns and Blood Pressure.
D. A. McCarron, U. S. Barzel, A. M. Sharma, U. Schorr, L. J. Appel, T. J. Moore, E. Obarzanek, and The DASH Collaborative Research Group (1997)
N. Engl. J. Med. 337, 636-638
   Full Text »
Aging, Acculturation, Salt Intake, and Hypertension in the Kuna of Panama.
N. K. Hollenberg, G. Martinez, M. McCullough, T. Meinking, D. Passan, M. Preston, A. Rivera, D. Taplin, and M. Vicaria-Clement (1997)
Hypertension 29, 171-176
   Abstract »    Full Text »    PDF »
Oral Calcium Supplementation Reduces Intraplatelet Free Calcium Concentration and Insulin Resistance in Essential Hypertensive Patients.
M. Sanchez, A. de la Sierra, A. Coca, E. Poch, V. Giner, and A. Urbano-Marquez (1997)
Hypertension 29, 531-536
   Abstract »    Full Text »    PDF »
Effect of Dietary Calcium and Milk Consumption on Risk of Thromboembolic Stroke in Older Middle-aged Men : The Honolulu Heart Program.
R. D. Abbott, J. D. Curb, B. L. Rodriguez, D. S. Sharp, C. M. Burchfiel, and K. Yano (1996)
Stroke 27, 813-818
   Abstract »    Full Text »
Dietary Calcium and Lower Blood Pressure: We Can All Benefit.
D. A. McCarron and D. Hatton (1996)
JAMA 275, 1128-1129
   Abstract »    PDF »
Endothelial Function in Deoxycorticosterone-NaCl Hypertension : Effect of Calcium Supplementation.
H. Makynen, M. Kahonen, X. Wu, P. Arvola, and I. Porsti (1996)
Circulation 93, 1000-1008
   Abstract »    Full Text »
Calcium-ATPase and Insulin in Adolescent Offspring of Essential Hypertensive Parents.
B. Grunfeld, M. Gimenez, M. Romo, L. Rabinovich, and R. B. Simsolo (1995)
Hypertension 26, 1070-1073
   Abstract »    Full Text »
Calcium Supplementation Attenuates an Enhanced Platelet Function in Salt-Loaded Mildly Hypertensive Patients.
K. Saito, H. Sano, J. Kawahara, and M. Yokoyama (1995)
Hypertension 26, 156-163
   Abstract »    Full Text »
Low Urinary Sodium Is Associated With Greater Risk of Myocardial Infarction Among Treated Hypertensive Men.
M. H. Alderman, S. Madhavan, H. Cohen, J. E. Sealey, and J. H. Laragh (1995)
Hypertension 25, 1144-1152
   Abstract »    Full Text »
Diet and health: what should we eat?.
W. Willett (1994)
Science 264, 532-537
   Abstract »    PDF »
National High Blood Pressure Education Program Working Group Report on Primary Prevention of Hypertension.
(1993)
Arch Intern Med 153, 186-208
   Abstract »    PDF »
The Calcium Deficiency Hypothesis of Hypertension.
D. A. McCARRON and C. D. MORRIS (1987)
Ann Intern Med 107, 919-922
   Abstract »    PDF »
Associations of Dietary Fat, Regional Adiposity, and Blood Pressure in Men.
P. T. Williams, S. P. Fortmann, R. B. Terry, S. C. Garay, K. M. Vranizan, N. Ellsworth, and P. D. Wood (1987)
JAMA 257, 3251-3256
   Abstract »    PDF »
Blood Pressure and Metabolic Effects of Calcium Supplementation in Normotensive White and Black Men.
R. M. Lyle, C. L. Melby, G. C. Hyner, J. W. Edmondson, J. Z. Miller, and M. H. Weinberger (1987)
JAMA 257, 1772-1776
   Abstract »    PDF »
The Calcium Hypothesis on Hypertension.
R. P. WEDEEN (1987)
Ann Intern Med 106, 472
   Abstract »    PDF »
The Calcium Deficiency Hypothesis of Hypertension: A Critique.
N. M. KAPLAN and R. B. MEESE (1986)
Ann Intern Med 105, 947-955
   Abstract »    PDF »
Calcium-Regulating Hormones in Essential Hypertension: Relation to Plasma Renin Activity and Sodium Metabolism.
L. M. RESNICK, F. B. MULLER, and J. H. LARAGH (1986)
Ann Intern Med 105, 649-654
   Abstract »    PDF »
Blood Pressure Response to Oral Calcium in Persons with Mild to Moderate Hypertension: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial.
D. A. MCCARRON and C. D. MORRIS (1985)
Ann Intern Med 103, 825-831
   Abstract »    PDF »
Calcium and Hypertension: The Emerging Connection.
L. M. RESNICK (1985)
Ann Intern Med 103, 944-946
   Abstract »    PDF »
Alcohol, Nutrient Intake, and Hypertension-Reply.
H. W. Gruchow, K. A. SOBOCINSKI, and J. J. Barboriak (1985)
JAMA 254, 504
   Abstract »    PDF »
Alcohol, Nutrient Intake, and Hypertension.
R. A. Holden (1985)
JAMA 254, 503-504
   Abstract »    PDF »
Alcohol, Nutrient Intake, and Hypertension in US Adults.
H. W. Gruchow, K. A. Sobocinski, and J. J. Barboriak (1985)
JAMA 253, 1567-1570
   Abstract »    PDF »
Non-Drug Treatment of Hypertension.
N. M. KAPLAN (1985)
Ann Intern Med 102, 359-373
   Abstract »    PDF »
Blood Lead Levels, Dietary Calcium, and Hypertension.
R. P. WEDEEN (1985)
Ann Intern Med 102, 403-404
   Abstract »    PDF »
Hypertension and calcium.
M Feinleib, C Lenfant, and S. Miller (1984)
Science 226, 384-389
   PDF »
Does a lack of calcium cause hypertension?.
G Kolata (1984)
Science 225, 705-706
   PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)