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Science 29 June 1984:
Vol. 224. no. 4656, pp. 1392 - 1398
DOI: 10.1126/science.6729459
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Articles

Science, Vol 224, Issue 4656, 1392-1398
Copyright © 1984 by American Association for the Advancement of Science

articles

Blood pressure and nutrient intake in the United States

DA McCarron, CD Morris, HJ Henry, and JL Stanton

A data base of the National Center for Health Statistics, Health and Nutrition Examination Survey I (HANES I), was used to perform a computer-assisted, comprehensive analysis of the relation of 17 nutrients to the blood pressure profile of adult Americans. Subjects were 10,372 individuals, 18 to 74 years of age, who denied a history of hypertension and intentional modification of their diet. Significant decreases in the consumption of calcium, potassium, vitamin A, and vitamin C were identified as the nutritional factors that distinguished hypertensive from normotensive subjects. Lower calcium intake was the most consistent factor in hypertensive individuals. Across the population, higher intakes of calcium, potassium, and sodium were associated with lower mean systolic blood pressure and lower absolute risk of hypertension. Increments of dietary calcium were also negatively correlated with body mass. Even though these correlations cannot be accepted as proof of causation, they have implications for future studies of the association of nutritional factors and dietary patterns with hypertension in America.


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   Abstract »    Full Text »
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   Abstract »    Full Text »
Diet and health: what should we eat?.
W. Willett (1994)
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   Abstract »    PDF »
National High Blood Pressure Education Program Working Group Report on Primary Prevention of Hypertension.
(1993)
Arch Intern Med 153, 186-208
   Abstract »    PDF »
The Calcium Deficiency Hypothesis of Hypertension.
D. A. McCARRON and C. D. MORRIS (1987)
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   Abstract »    PDF »
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P. T. Williams, S. P. Fortmann, R. B. Terry, S. C. Garay, K. M. Vranizan, N. Ellsworth, and P. D. Wood (1987)
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   Abstract »    PDF »
Blood Pressure and Metabolic Effects of Calcium Supplementation in Normotensive White and Black Men.
R. M. Lyle, C. L. Melby, G. C. Hyner, J. W. Edmondson, J. Z. Miller, and M. H. Weinberger (1987)
JAMA 257, 1772-1776
   Abstract »    PDF »
The Calcium Hypothesis on Hypertension.
R. P. WEDEEN (1987)
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   Abstract »    PDF »
The Calcium Deficiency Hypothesis of Hypertension: A Critique.
N. M. KAPLAN and R. B. MEESE (1986)
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   Abstract »    PDF »
Calcium-Regulating Hormones in Essential Hypertension: Relation to Plasma Renin Activity and Sodium Metabolism.
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   Abstract »    PDF »
Blood Pressure Response to Oral Calcium in Persons with Mild to Moderate Hypertension: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial.
D. A. MCCARRON and C. D. MORRIS (1985)
Ann Intern Med 103, 825-831
   Abstract »    PDF »
Calcium and Hypertension: The Emerging Connection.
L. M. RESNICK (1985)
Ann Intern Med 103, 944-946
   Abstract »    PDF »
Alcohol, Nutrient Intake, and Hypertension-Reply.
H. W. Gruchow, K. A. SOBOCINSKI, and J. J. Barboriak (1985)
JAMA 254, 504
   Abstract »    PDF »
Alcohol, Nutrient Intake, and Hypertension.
R. A. Holden (1985)
JAMA 254, 503-504
   Abstract »    PDF »
Alcohol, Nutrient Intake, and Hypertension in US Adults.
H. W. Gruchow, K. A. Sobocinski, and J. J. Barboriak (1985)
JAMA 253, 1567-1570
   Abstract »    PDF »
Non-Drug Treatment of Hypertension.
N. M. KAPLAN (1985)
Ann Intern Med 102, 359-373
   Abstract »    PDF »
Blood Lead Levels, Dietary Calcium, and Hypertension.
R. P. WEDEEN (1985)
Ann Intern Med 102, 403-404
   Abstract »    PDF »
Hypertension and calcium.
M Feinleib, C Lenfant, and S. Miller (1984)
Science 226, 384-389
   PDF »
Does a lack of calcium cause hypertension?.
G Kolata (1984)
Science 225, 705-706
   PDF »


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