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Science 22 June 1984:
Vol. 224. no. 4655, pp. 1359 - 1361
DOI: 10.1126/science.6328654
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Articles

Science, Vol 224, Issue 4655, 1359-1361
Copyright © 1984 by American Association for the Advancement of Science

articles

Decreased neuronal inhibition in vitro after long-term administration of ethanol

D Durand and PL Carlen

The pathophysiology of brain dysfunction was studied with an animal model of chronic alcoholism. Rats were fed a liquid diet with or without ethanol for 20 weeks and then the diet without ethanol for three more weeks. Hippocampal slices were prepared and intracellular recordings were obtained from dentate granule and CA1 cells. Significant depression of orthodromically elicited inhibitory postsynaptic potentials and postspike afterhyperpolarizations was observed in neurons from ethanol-exposed animals. No differences were observed in other active or passive membrane characteristics. These results suggest that a loss of neuronal inhibition could contribute to brain dysfunction in chronic alcoholism.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Early Alcohol Exposure Induces Persistent Alteration of Cortical Columnar Organization and Reduced Orientation Selectivity in the Visual Cortex.
A. E. Medina, T. E. Krahe, and A. S. Ramoa (2005)
J Neurophysiol 93, 1317-1325
   Abstract »    Full Text »    PDF »
Neonatal Alcohol Exposure Induces Long-Lasting Impairment of Visual Cortical Plasticity in Ferrets.
A. E. Medina, T. E. Krahe, D. M. Coppola, and A. S. Ramoa (2003)
J. Neurosci. 23, 10002-10012
   Abstract »    Full Text »    PDF »


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