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Science 22 June 1984:
Vol. 224. no. 4655, pp. 1348 - 1350
DOI: 10.1126/science.6374896
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Articles

Science, Vol 224, Issue 4655, 1348-1350
Copyright © 1984 by American Association for the Advancement of Science

articles

Autoantibodies to a 64-kilodalton islet cell protein precede the onset of spontaneous diabetes in the BB rat

S Baekkeskov, T Dyrberg, and A Lernmark

Spontaneous insulin-dependent diabetes mellitus (IDDM) in the BB rat is associated with the presence of antibodies to a 64-kilodalton rat islet cell protein. These protein antibodies appeared in young animals and remained for as long as 8 weeks before the clinical onset of IDDM. Antibodies to a 64-kilodalton human islet cell protein were found to be associated with human IDDM. Detection of the antibodies may therefore be used to predict an early immune reaction against pancreatic B cells.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Evidence of a Functional Role for Mast Cells in the Development of Type 1 Diabetes Mellitus in the BioBreeding Rat.
R. Geoffrey, S. Jia, A. E. Kwitek, J. Woodliff, S. Ghosh, A. Lernmark, X. Wang, and M. J. Hessner (2006)
J. Immunol. 177, 7275-7286
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A Type 1 Diabetes-related Protein from Wheat (Triticum aestivum). cDNA CLONE OF A WHEAT STORAGE GLOBULIN, Glb1, LINKED TO ISLET DAMAGE.
A. J. MacFarlane, K. M. Burghardt, J. Kelly, T. Simell, O. Simell, I. Altosaar, and F. W. Scott (2003)
J. Biol. Chem. 278, 54-63
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Transient Antiislet Autoantibodies: Infrequent Occurrence and Lack of Association with "Genetic" Risk Factors.
J. Yu, L. Yu, T. L. Bugawan, H. A. Erlich, K. Barriga, M. Hoffman, M. Rewers, and G. S. Eisenbarth (2000)
J. Clin. Endocrinol. Metab. 85, 2421-2428
   Abstract »    Full Text »
Autoimmune diseases: the failure of self tolerance.
A. Sinha, M. Lopez, and H. McDevitt (1990)
Science 248, 1380-1388
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