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Science 22 June 1984:
Vol. 224. no. 4655, pp. 1346 - 1348
DOI: 10.1126/science.6203171
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Articles

Science, Vol 224, Issue 4655, 1346-1348
Copyright © 1984 by American Association for the Advancement of Science

articles

Potentiation of bleomycin lethality by anticalmodulin drugs: a role for calmodulin in DNA repair

JG Chafouleas, WE Bolton, and AR Means

Treatment of exponentially growing Chinese hamster ovary cells with bleomycin causes a dose-dependent decrease in cell survival due to DNA damage. This lethal effect can be potentiated by the addition of a nonlethal dose of the anticalmodulin drug N-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide ( W13 ) but not its inactive analog N-(4-aminobutyl)-2-naphthalenesulfonamide ( W12 ). By preventing the repair of damaged DNA, W13 also inhibits recovery from potentially lethal damage induced by bleomycin. These data suggest a role for calmodulin in the DNA repair pathway.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The antipsychotic drug trifluoperazine inhibits DNA repair and sensitizes non small cell lung carcinoma cells to DNA double-strand break induced cell death.
A. G. Polischouk, A. Holgersson, D. Zong, B. Stenerlow, H. L. Karlsson, L. Moller, K. Viktorsson, and R. Lewensohn (2007)
Mol. Cancer Ther. 6, 2303-2309
   Abstract »    Full Text »    PDF »
Nuclear calmodulin/62 kDa calmodulin-binding protein complexes in interphasic and mitotic cells.
M Portoles, M Faura, J Renau-Piqueras, F. Iborra, R Saez, C Guerri, J Serratosa, E Rius, and O Bachs (1994)
J. Cell Sci. 107, 3601-3614
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)