Science 22 June 1984: Vol. 224. no. 4655, pp. 1312 - 1316 DOI: 10.1126/science.6427923

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Articles

In vivo expansion of T reg cells with IL-2-mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression.

K. E. Webster, S. Walters, R. E. Kohler, T. Mrkvan, O. Boyman, C. D. Surh, S. T. Grey, and J. Sprent (2009)
J. Exp. Med. 206, 751-760
 |  Abstract »  |  Full Text »  |  PDF »

Long-term increases in lymphocytes and platelets in human T-lymphotropic virus type II infection.

M. T. Bartman, Z. Kaidarova, D. Hirschkorn, R. A. Sacher, J. Fridey, G. Garratty, J. Gibble, J. W. Smith, B. Newman, A. E. Yeo, et al. (2008)
Blood 112, 3995-4002
 |  Abstract »  |  Full Text »  |  PDF »

African Trypanosomiasis: Naturally Occurring Regulatory T Cells Favor Trypanotolerance by Limiting Pathology Associated with Sustained Type 1 Inflammation.

M. Guilliams, G. Oldenhove, W. Noel, M. Herin, L. Brys, P. Loi, V. Flamand, M. Moser, P. De Baetselier, and A. Beschin (2007)
J. Immunol. 179, 2748-2757
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IL-2 Regulates Expansion of CD4+ T Cell Populations by Affecting Cell Death: Insights from Modeling CFSE Data.

V. V. Ganusov, D. Milutinovic, and R. J. De Boer (2007)
J. Immunol. 179, 950-957
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Identifying Druglike Inhibitors of Myelin-Reactive T Cells by Phenotypic High-Throughput Screening of a Small-Molecule Library.

C. Rossi, D. Padmanaban, J. Ni, L.-A. Yeh, M. A. Glicksman, and H. Waldner (2007)
J Biomol Screen 12, 481-489
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Activation of Adenosine 2A Receptors Attenuates Allograft Rejection and Alloantigen Recognition.

C. P. Sevigny, L. Li, A. S. Awad, L. Huang, M. McDuffie, J. Linden, P. I. Lobo, and M. D. Okusa (2007)
J. Immunol. 178, 4240-4249
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A model of immune regulation as a consequence of randomized lymphocyte division and death times.

E. D. Hawkins, M. L. Turner, M. R. Dowling, C. van Gend, and P. D. Hodgkin (2007)
PNAS 104, 5032-5037
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CD27 mediates interleukin-2-independent clonal expansion of the CD8+ T cell without effector differentiation.

J. M. Carr, M. J. Carrasco, J. E. D. Thaventhiran, P. J. Bambrough, M. Kraman, A. D. Edwards, A. Al-Shamkhani, and D. T. Fearon (2006)
PNAS 103, 19454-19459
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Differential regulation of T-cell growth by IL-2 and IL-15.

G. H. Cornish, L. V. Sinclair, and D. A. Cantrell (2006)
Blood 108, 600-608
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Effects of {beta}-glucan obtained from the Chinese herb Astragalus membranaceus and lipopolysaccharide challenge on performance, immunological, adrenal, and somatotropic responses of weanling pigs.

X. F. Mao, X. S. Piao, C. H. Lai, D. F. Li, J. J. Xing, and B. L. Shi (2005)
J Anim Sci 83, 2775-2782
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Contrasting Effects of Low-Dose IL-2 on Vaccine-Boosted Simian Immunodeficiency Virus (SIV)-Specific CD4+ and CD8+ T Cells in Macaques Chronically Infected with SIVmac251.

J. Nacsa, Y. Edghill-Smith, W.-P. Tsai, D. Venzon, E. Tryniszewska, A. Hryniewicz, M. Moniuszko, A. Kinter, K. A. Smith, and G. Franchini (2005)
J. Immunol. 174, 1913-1921
 |  Abstract »  |  Full Text »  |  PDF »

A Late, Prolonged Activation of the Phosphatidylinositol 3-Kinase Pathway Is Required for T Cell Proliferation.

F. V. Lali, J. Crawley, D. A. McCulloch, and B. M. J. Foxwell (2004)
J. Immunol. 172, 3527-3534
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Sustained IL-12 Signaling Is Required for Th1 Development.

V. Athie-Morales, H. H. Smits, D. A. Cantrell, and C. M. U. Hilkens (2004)
J. Immunol. 172, 61-69
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of the Chromosomal Binding Sites and Dimerization Partners of the Viral Oncoprotein Meq in Marek's Disease Virus-Transformed T Cells.

A. M. Levy, Y. Izumiya, P. Brunovskis, L. Xia, M. S. Parcells, S. M. Reddy, L. Lee, H.-W. Chen, and H.-J. Kung (2003)
J. Virol. 77, 12841-12851
 |  Abstract »  |  Full Text »  |  PDF »

Dual upregulation of Fas and Bax promotes alloreactive T cell apoptosis in IL-10 gene targeting of cardiac allografts.

T. C. Tung, K. Oshima, G. Cui, H. Laks, and L. Sen (2003)
Am J Physiol Heart Circ Physiol 285, H964-H973
 |  Abstract »  |  Full Text »  |  PDF »

Stochastic Model of T Cell Proliferation: A Calculus Revealing IL-2 Regulation of Precursor Frequencies, Cell Cycle Time, and Survival.

E. K. Deenick, A. V. Gett, and P. D. Hodgkin (2003)
J. Immunol. 170, 4963-4972
 |  Abstract »  |  Full Text »  |  PDF »

A Constitutively Active NFATc1 Mutant Induces a Transformed Phenotype in 3T3-L1 Fibroblasts.

J. W. Neal and N. A. Clipstone (2003)
J. Biol. Chem. 278, 17246-17254
 |  Abstract »  |  Full Text »  |  PDF »

Clonal Anergy Is Maintained Independently of T Cell Proliferation.

S. Colombetti, F. Benigni, V. Basso, and A. Mondino (2002)
J. Immunol. 169, 6178-6186
 |  Abstract »  |  Full Text »  |  PDF »

Correlation of Transcriptional Repression by p21SNFT with Changes in DNA{middle dot}NF-AT Complex Interactions.

K. E. Bower, R. W. Zeller, W. Wachsman, T. Martinez, and K. L. McGuire (2002)
J. Biol. Chem. 277, 34967-34977
 |  Abstract »  |  Full Text »  |  PDF »

Mycophenolic Acid Inhibits IL-2-Dependent T Cell Proliferation, But Not IL-2-Dependent Survival and Sensitization to Apoptosis.

L. Quemeneur, M. Flacher, L.-M. Gerland, M. Ffrench, J.-P. Revillard, and N. Bonnefoy-Berard (2002)
J. Immunol. 169, 2747-2755
 |  Abstract »  |  Full Text »  |  PDF »

Control of IL-2R{alpha} gene expression: structural changes within the proximal enhancer/core promoter during T-cell development.

J.-H. Yeh, S. Spicuglia, S. Kumar, A. Sanchez-Sevilla, P. Ferrier, and J. Imbert (2002)
Nucleic Acids Res. 30, 1944-1951
 |  Abstract »  |  Full Text »  |  PDF »

LFA-1 integrin and the microtubular cytoskeleton are involved in the Ca2+-mediated regulation of the activity of the tyrosine kinase PYK2 in T cells.

J. L. Rodriguez-Fernandez, L. Sanchez-Martin, C. A. de Frutos, D. Sancho, M. Robinson, F. Sanchez-Madrid, and C. Cabanas (2002)
J. Leukoc. Biol. 71, 520-530
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The Art of the Probable: System Control in the Adaptive Immune System.

R. N. Germain (2001)
Science 293, 240-245
 |  Abstract »  |  Full Text »

Phase 1B Study of Subcutaneously Administered Interleukin 2 in Combination with 13-cis Retinoic Acid as Maintenance Therapy in Advanced Cancer.

F. Recchia, S. De Filippis, M. Rosselli, G. Saggio, A. Cesta, L. Fumagalli, and S. Rea (2001)
Clin. Cancer Res. 7, 1251-1257
 |  Abstract »  |  Full Text »

Three-Cell Interactions in T Cell-Mediated Suppression? A Mathematical Analysis of Its Quantitative Implications.

K. Leon, R. Perez, A. Lage, and J. Carneiro (2001)
J. Immunol. 166, 5356-5365
 |  Abstract »  |  Full Text »  |  PDF »

A ligand-receptor signaling threshold model of stem cell differentiation control: a biologically conserved mechanism applicable to hematopoiesis.

P. W. Zandstra, D. A. Lauffenburger, and C. J. Eaves (2000)
Blood 96, 1215-1222
 |  Abstract »  |  Full Text »  |  PDF »

Long-term kinetics of T cell production in HIV-infected subjects treated with highly active antiretroviral therapy.

S. Fleury, G. P. Rizzardi, A. Chapuis, G. Tambussi, C. Knabenhans, E. Simeoni, J.-Y. Meuwly, J.-M. Corpataux, A. Lazzarin, F. Miedema, et al. (2000)
PNAS 97, 5393-5398
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Lymphoid Homeostasis by IL-2 Receptor Signals In Vivo.

D. T. M. Leung, S. Morefield, and D. M. Willerford (2000)
J. Immunol. 164, 3527-3534
 |  Abstract »  |  Full Text »  |  PDF »

The Mode and Duration of Anti-CD28 Costimulation Determine Resistance to Infection by Macrophage-Tropic Strains of Human Immunodeficiency Virus Type 1 In Vitro.

J. R. Creson, A. A. Lin, Q. Li, D. F. Broad, M. R. Roberts, and S. J. Anderson (1999)
J. Virol. 73, 9337-9347
 |  Abstract »  |  Full Text »  |  PDF »

p70s6k Integrates Phosphatidylinositol 3-Kinase and Rapamycin-Regulated Signals for E2F Regulation in T Lymphocytes.

P. Brennan, J. W. Babbage, G. Thomas, and D. Cantrell (1999)
Mol. Cell. Biol. 19, 4729-4738
 |  Abstract »  |  Full Text »  |  PDF »

Mechanisms of T-Cell Activation by Human T-Cell Lymphotropic Virus Type I.

P. Hollsberg (1999)
Microbiol. Mol. Biol. Rev. 63, 308-333
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-2 (IL-2) Regulates the Accessibility of the IL-2-Responsive Enhancer in the IL-2 Receptor alpha  Gene to Transcription Factors.

C. Rusterholz, P. C. Henrioud, and M. Nabholz (1999)
Mol. Cell. Biol. 19, 2681-2689
 |  Abstract »  |  Full Text »  |  PDF »

c-Rel is crucial for lymphocyte proliferation but dispensable for T cell effector function.

H.-C. Liou, Z. Jin, J. Tumang, S. Andjelic, K. A. Smith, and M.-L. Liou (1999)
Int. Immunol. 11, 361-371
 |  Abstract »  |  Full Text »  |  PDF »

CD4-Mediated Inhibiton of IL-2 Production in Activated T Cells.

M. Bonnard, L. Haughn, and M. Julius (1999)
J. Immunol. 162, 1252-1260
 |  Abstract »  |  Full Text »  |  PDF »

IL-4 Selectively Inhibits IL-2-Triggered Stat5 Activation, But Not Proliferation, in Human T Cells.

A. Castro, T. K. Sengupta, D. C. Ruiz, E. Yang, and L. B. Ivashkiv (1999)
J. Immunol. 162, 1261-1269
 |  Abstract »  |  Full Text »  |  PDF »

T Cell Receptor (TCR) Antagonism without a Negative Signal: Evidence from T Cell Hybridomas Expressing Two Independent TCRs.

S. H. Stotz, L. Bolliger, F. R. Carbone, and E. Palmer (1999)
J. Exp. Med. 189, 253-264
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-6 (IL-6) Prevents Activation-Induced Cell Death: IL-2-Independent Inhibition of Fas/fasL Expression and Cell Death.

E. Ayroldi, O. Zollo, L. Cannarile, F. D' Adamio, U. Grohmann, D. V. Delfino, and C. Riccardi (1998)
Blood 92, 4212-4219
 |  Abstract »  |  Full Text »  |  PDF »

Selective Induction of CD8+ Cytotoxic T Lymphocyte Effector Function by Staphylococcus Enterotoxin B.

C. L. Fuller and V. L. Braciale (1998)
J. Immunol. 161, 5179-5186
 |  Abstract »  |  Full Text »  |  PDF »

Cell division regulates the T cell cytokine repertoire, revealing a mechanism underlying immune class regulation.

A. V. Gett and P. D. Hodgkin (1998)
PNAS 95, 9488-9493
 |  Abstract »  |  Full Text »  |  PDF »

Dual Role of Ceramide in the Control of Apoptosis Following IL-2 Withdrawal.

I. Flores, C. Martinez-A, Y. A. Hannun, and I. Merida (1998)
J. Immunol. 160, 3528-3533
 |  Abstract »  |  Full Text »  |  PDF »

Production of IL-10 by Human Natural Killer Cells Stimulated with IL-2 and/or IL-12.

P. T. Mehrotra, R. P. Donnelly, S. Wong, H. Kanegane, A. Geremew, H. S. Mostowski, K. Furuke, J. P. Siegel, and E. T. Bloom (1998)
J. Immunol. 160, 2637-2644
 |  Abstract »  |  Full Text »  |  PDF »

Proteolytic Cleavage of CD25, the alpha  Subunit of the Human T Cell Interleukin 2 Receptor, by Der p 1, a Major Mite Allergen with Cysteine Protease Activity.

O. Schulz, H. F. Sewell, and F. Shakib (1998)
J. Exp. Med. 187, 271-275
 |  Abstract »  |  Full Text »  |  PDF »

p21WAF1 is dynamically associated with JNK in human T-lymphocytes during cell cycle progression.

R Patel, B Bartosch, and J. Blank (1998)
J. Cell Sci. 111, 2247-2255
 |  Abstract »  |  PDF »

Antigen Is Required for the Activation of Effector Activities, whereas Interleukin 2 Is Required for the Maintenance of Memory in Ovalbumin-specific, CD8+ Cytotoxic T Lymphocytes.

Y. Ke, H. Ma, and J. A. Kapp (1998)
J. Exp. Med. 187, 49-57
 |  Abstract »  |  Full Text »  |  PDF »

A Point Mutation in Interleukin-2 That Alters Ligand Internalization.

D. Z. Chang, Z. Wu, and T. L. Ciardelli (1996)
J. Biol. Chem. 271, 13349-13355
 |  Abstract »  |  Full Text »  |  PDF »

Nuclear Appearance of a Factor That Binds the CD28 Response Element within the Interleukin-2 Enhancer Correlates with Interleukin-2 Production.

A. Civil, A. Bakker, I. Rensink, S. Doerre, L. A. Aarden, and C. L.Verweij (1996)
J. Biol. Chem. 271, 8321-8327
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-12 Synergizes With Interleukin-2 to Generate Lymphokine-Activated Killer Activity in Peripheral Blood Mononuclear Cells Cultured in Ovarian Cancer Ascitic Fluid.

D. P. J. Barton, D. K. Blanchard, C. Duan, W. S. Roberts, D. Cavanagh, S. DeCesare, and J. Y. Djeu (1995)
Reproductive Sciences 2, 762-771
 |  Abstract »  |  PDF »

A Comparison of the Interaction of Shc and the Tyrosine Kinase ZAP-70 with the T Cell Antigen Receptor [IMAGE] Chain Tyrosine-based Activation Motif.

N. Osman, S. C. Lucas, H. Turner, and D. Cantrell (1995)
J. Biol. Chem. 270, 13981-13986
 |  Abstract »  |  Full Text »  |  PDF »

Mouse Interleukin-2 Receptor [IMAGE] Gene Expression.

E. Soldaini, M. Pla, F. Beermann, E. Espel, P. Corthésy, S. Barangé, G. A. Waanders, H. R. MacDonald, and M. Nabholz (1995)
J. Biol. Chem. 270, 10733-10742
 |  Abstract »  |  Full Text »  |  PDF »

Mouse Interleukin-2 Receptor [IMAGE] Gene Expression.

P. Sperisen, S. M. Wang, E. Soldaini, M. Pla, C. Rusterholz, P. Bucher, P. Corthésy, P. Reichenbach, and M. Nabholz (1995)
J. Biol. Chem. 270, 10743-10753
 |  Abstract »  |  Full Text »  |  PDF »

Usefulness of Soluble Interleukin 2 Receptor in Differentiating Tuberculous and Carcinomatous Pleural Effusions.

S.-C. Chang, Y.-T. Hsu, Y.-C. Chen, and C.-Y. Lin (1994)
Arch Intern Med 154, 1097-1101
 |  Abstract »  |  PDF »

Dominant interfering alleles define a role for c-Myb in T-cell development..

P Badiani, P Corbella, D Kioussis, J Marvel, and K Weston (1994)
Genes & Dev. 8, 770-782
 |  Abstract »  |  PDF »

PAC-1: a mitogen-induced nuclear protein tyrosine phosphatase.

P. Rohan, P Davis, C. Moskaluk, M Kearns, H Krutzsch, U Siebenlist, and K Kelly (1993)
Science 259, 1763-1766
 |  Abstract »  |  PDF »

Transplant Rejection: Mechanisms and Treatment.

C. Chandler and E. Passaro Jr (1993)
Arch Surg 128, 279-283
 |  Abstract »  |  PDF »

Elevated Levels of Soluble Interleukin 2 Receptor and Tumor Necrosis Factor in Nasopharyngeal Carcinoma.

M.-M. Hsu, J.-Y. Ko, and Y.-L. Chang (1991)
Arch Otolaryngol Head Neck Surg 117, 1257-1259
 |  Abstract »  |  PDF »

Activation of early gene expression in T lymphocytes by Oct-1 and an inducible protein, OAP40.

K. Ullman, W. Flanagan, C. Edwards, and G. Crabtree (1991)
Science 254, 558-562
 |  Abstract »  |  PDF »

Single cell assay of a transcription factor reveals a threshold in transcription activated by signals emanating from the T-cell antigen receptor..

S Fiering, J P Northrop, G P Nolan, P S Mattila, G R Crabtree, and L A Herzenberg (1990)
Genes & Dev. 4, 1823-1834
 |  Abstract »  |  PDF »

Psychological Stress--Induced Modulation of Interleukin 2 Receptor Gene Expression and Interleukin 2 Production in Peripheral Blood Leukocytes.

R. Glaser, S. Kennedy, W. P. Lafuse, R. H. Bonneau, C. Speicher, J. Hillhouse, and J. K. Kiecolt-Glaser (1990)
Arch Gen Psychiatry 47, 707-712
 |  Abstract »  |  PDF »

G1/S transition in normal human T-lymphocytes requires the nuclear protein encoded by c-myb.

A. Gewirtz, G Anfossi, D Venturelli, S Valpreda, R Sims, and B Calabretta (1989)
Science 245, 180-183
 |  Abstract »  |  PDF »

Contingent genetic regulatory events in T lymphocyte activation.

G. Crabtree (1989)
Science 243, 355-361
 |  Abstract »  |  PDF »

Interleukin-2: inception, impact, and implications.

K. Smith (1988)
Science 240, 1169-1176
 |  Abstract »  |  PDF »

Hemorrhage Without Tissue Trauma Produces Immunosuppression and Enhances Susceptibility to Sepsis.

R. N. Stephan, T. S. Kupper, A. S. Geha, A. E. Baue, and I. H. Chaudry (1987)
Arch Surg 122, 62-68
 |  Abstract »  |  PDF »

The Human Interleukin-2 Receptor: Normal and Abnormal Expression in T Cells and in Leukemias Induced by the Human T-Lymphotropic Retroviruses.

W. C. GREENE, W. J. LEONARD, J. M. DEPPER, D. L. NELSON, and T. A. WALDMANN (1986)
Ann Intern Med 105, 560-572
 |  Abstract »  |  PDF »

Interleukin-2 induction of T-cell G1 progression and c-myb expression.

J. Stern and K. Smith (1986)
Science 233, 203-206
 |  Abstract »  |  PDF »

The structure, function, and expression of interleukin-2 receptors on normal and malignant lymphocytes.

T. Waldmann (1986)
Science 232, 727-732
 |  Abstract »  |  PDF »

Identification of a T helper cell-derived lymphokine that activates resting T lymphocytes.

C Milanese, N. Richardson, and E. Reinherz (1986)
Science 231, 1118-1122
 |  Abstract »  |  PDF »

The Effects of Hemorrhage and Trauma on Interleukin 2 Production.

E. Abraham and R. F. Regan (1985)
Arch Surg 120, 1341-1344
 |  Abstract »  |  PDF »

Tumor Necrosis Factor-alpha Production Is Differently Regulated in gamma delta and alpha beta Human T Lymphocytes.

V. Lafont, J. Liautard, A. Gross, J. P. Liautard, and J. Favero (2000)
J. Biol. Chem. 275, 19282-19287
 |  Abstract »  |  Full Text »  |  PDF »

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