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Science 15 June 1984:
Vol. 224. no. 4654, pp. 1245 - 1247
DOI: 10.1126/science.6328652
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Articles

Science, Vol 224, Issue 4654, 1245-1247
Copyright © 1984 by American Association for the Advancement of Science

articles

Reinitiation of growth in senescent mouse mammary epithelium in response to cholera toxin

CW Daniel, GB Silberstein, and P Strickland

Several lines of mouse mammary tissue that had been serially transplanted until mitotic senescence was reached were exposed in vivo to plastic implants that slowly released cholera toxin. Gland tissue surrounding the implants displayed new end buds, indicating reinitiation of growth and morphogenesis. The ability of cholera toxin, which elevates intracellular adenosine 3',5'-monophosphate, to temporarily reverse the senescent phenotype suggests that this mitotic dysfunction results not from generalized cellular deterioration but from specific changes in cell regulation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Reversible inhibition of mammary gland growth by transforming growth factor-beta.
G. Silberstein and C. Daniel (1987)
Science 237, 291-293
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