Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 15 June 1984:
Vol. 224. no. 4654, pp. 1237 - 1239
DOI: 10.1126/science.6328650
Prev | Table of Contents | Next

Articles

Science, Vol 224, Issue 4654, 1237-1239
Copyright © 1984 by American Association for the Advancement of Science

articles

Sodium-coupled sugar transport: effects on intracellular sodium activities and sodium-pump activity

RL Hudson and SG Schultz

Intracellular sodium activities, (Na)c, were determined in Necturus small intestine before and after addition of galactose to the mucosal bathing solution. In the absence of galactose, (Na)c averaged 12 millimoles per liter. Within 2 minutes after the addition of galactose to the mucosal solution, (Na)c increased to a mean value of 20 millimoles per liter and then declined, in parallel with an increase in transcellular sodium transport, to a value that did not differ significantly from that observed in the absence of the sugar. The final steady state in the presence of galactose was characterized by a three- to fourfold increase in the rate of transcellular Na+ transport in the absence of a significant increase in (Na)c. Thus, the increase in steady-state basolateral pump activity cannot be attributed to an increase in the intracellular sodium transport pool.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A quantitative analysis of cell volume and resting potential determination and regulation in excitable cells.
J. A. Fraser and C. L.-H. Huang (2004)
J. Physiol. 559, 459-478
   Abstract »    Full Text »    PDF »
Analysis of the sodium recirculation theory of solute-coupled water transport in small intestine.
E. H. Larsen, J. B. Sorensen, and J. N. Sorensen (2002)
J. Physiol. 542, 33-50
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)